Borská L, Fiala Z, Krejsek J, Andrýs C, Vokurková D, Hamáková K, Kremlácek J, Ettler K
Institute of Pathological Physiology, Charles University in Prague, Faculty of Medicine in Hradec Kralové, Hradec Králové, Czech Republic.
Physiol Res. 2006;55(6):699-706. doi: 10.33549/physiolres.930928.
Psoriasis is one of the most frequent inflammatory skin diseases in which abnormal individual immune reactivity plays an important role. The aim of the present study was to describe selected immunological changes, concerning pro-inflammatory cytokines (TNF-alpha, IL-8) and adhesion molecules (sE-selectin, sP-selectin, sICAM-1), in 56 patients cured by Goeckerman's therapy (GT). GT includes dermal application of crude coal tar (containing polycyclic aromatic hydrocarbons) and exposure to UV radiation. When compared with the control group (healthy blood donors), the patients before GT had significantly increased serum levels of sE-selectin (p<0.001), sP-selectin (p<0.001), sICAM-1 (p<0.001) and IL-8 (p<0.001). Significantly decreased serum levels of sE-selectin (p<0.05) and significantly increased serum levels of IL-8 (p<0.05) were found after GT therapy. Serum levels of sICAM significantly correlated with the disease activity and with serum levels of sE-selectin. The level of PASI score (Psoriasis Area and Severity Index) significantly decreased after GT (p<0.001) and confirms the high efficiency GT. These findings confirmed that pro-inflammatory chemokine (IL-8) and adhesion molecules (sE-selectin, sP-selectin, sICAM-1) play an important role in the development and regulation of inflammation in psoriasis. Determination of sE-selectin and sICAM seems to be a promising marker of psoriasis's activity. Chemokine pathway (IL-8) and TNF-alpha activity seem to be modulated by Goeckerman's therapy (polycyclic aromatic hydrocarbons).
银屑病是最常见的炎症性皮肤病之一，个体免疫反应异常在其中起着重要作用。本研究的目的是描述56例接受格克曼疗法（GT）治愈的患者中，与促炎细胞因子（TNF-α、IL-8）和黏附分子（sE-选择素、sP-选择素、sICAM-1）相关的特定免疫变化。GT包括在皮肤上涂抹粗煤焦油（含多环芳烃）并暴露于紫外线辐射。与对照组（健康献血者）相比，接受GT治疗前的患者血清中sE-选择素（p<0.001）、sP-选择素（p<0.001）、sICAM-1（p<0.001）和IL-8（p<0.001）水平显著升高。GT治疗后发现血清中sE-选择素水平显著降低（p<0.05），而IL-8血清水平显著升高（p<0.05）。血清中sICAM水平与疾病活动度及sE-选择素血清水平显著相关。GT治疗后PASI评分（银屑病面积和严重程度指数）水平显著降低（p<0.001），证实了GT的高效性。这些发现证实促炎趋化因子（IL-8）和黏附分子（sE-选择素、sP-选择素、sICAM-1）在银屑病炎症的发生和调节中起重要作用。测定sE-选择素和sICAM似乎是银屑病活动度的一个有前景的标志物。趋化因子途径（IL-8）和TNF-α活性似乎受到格克曼疗法（多环芳烃）的调节。
