选择素在斑秃中的作用。
The role of selectins in alopecia areata.
作者信息
Sudnik Wiesława, Dańczak-Pazdrowska Aleksandra, Silny Wojciech, Osmola-Mańkowska Agnieszka, Pazdrowski Jakub, Polańska Adriana
机构信息
Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Zygmunt Adamski MD, PhD.
Great Poland Center of Allergology and Aesthetic Dermatology "Art Clinic", Poznan, Poland. Head of Center: Prof. Wojciech Silny MD, PhD.
出版信息
Postepy Dermatol Alergol. 2015 Feb;32(1):27-32. doi: 10.5114/pdia.2014.40946. Epub 2015 Feb 3.
INTRODUCTION
One of the main histopathological features of alopecia areata (AA) is a lymphocytic infiltration that surrounds hair follicles. Soluble forms of E, L, P-selectins are known indicators of ongoing inflammation. There are no studies regarding the assessment of their contribution in AA.
AIM
To assess serum concentrations of selectins (E-selectin, L-selectin and P-selectin) in patients with AA in relation to selected clinical parameters, including disease severity and activity.
MATERIAL AND METHODS
Sixty-four patients with AA were involved in the study. The diagnosis was based on physical examination and photodermoscopy. The control group consisted of 40 healthy subjects. The serum concentrations of soluble E-selectin, L-selectin and P-selectin were detected with ELISA method.
RESULTS
Statistically significantly higher levels of E, P, L-selectins were found in AA patients as compared with the healthy group. Serum concentrations of soluble forms of E- and L-selectins correlated with the severity of the disease, while E-selectin with activity of AA.
CONCLUSIONS
This study shows that selectins may play an important role in the pathogenesis of AA and may be a target of future therapies in this disease.
引言
斑秃（AA）的主要组织病理学特征之一是淋巴细胞浸润环绕毛囊。可溶性E、L、P选择素是炎症活动的已知指标。尚无关于评估它们在斑秃中作用的研究。
目的
评估斑秃患者血清中选择素（E选择素、L选择素和P选择素）的浓度与选定临床参数的关系，包括疾病严重程度和活动度。
材料与方法
64例斑秃患者参与本研究。诊断基于体格检查和皮肤镜检查。对照组由40名健康受试者组成。采用酶联免疫吸附测定（ELISA）法检测血清中可溶性E选择素、L选择素和P选择素的浓度。
结果
与健康组相比，斑秃患者血清中E、P、L选择素水平在统计学上显著更高。可溶性E选择素和L选择素的血清浓度与疾病严重程度相关，而E选择素与斑秃活动度相关。
结论
本研究表明，选择素可能在斑秃发病机制中起重要作用，可能成为该疾病未来治疗的靶点。
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