曲内酯A-D，四种源自海洋曲霉属真菌的半萜类化合物。

Tropolactones A-D, four meroterpenoids from a marine-derived fungus of the genus Aspergillus.

作者信息

Cueto Mercedes, MacMillan John B, Jensen Paul R, Fenical William

机构信息

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego La Jolla, CA 92093-0204, USA.

出版信息

Phytochemistry. 2006 Aug;67(16):1826-31. doi: 10.1016/j.phytochem.2006.01.008. Epub 2006 Feb 28.

DOI:10.1016/j.phytochem.2006.01.008

PMID:16500687

Abstract

Four cytotoxic meroterpenoids, tropolactones A-D, were isolated from the whole broth extract of a marine-derived fungus of the genus Aspergillus. The structures of the meroterpenoids were established through a variety of two-dimensional NMR techniques. The absolute configuration of tropolactone A was determined using the modified Mosher method. Tropolactones A-C contain an interesting substituted 2,4,6-cycloheptatriene (tropone) ring, which presumably arises through an oxidative ring expansion from tropolactone D. Tropolactones A, B and C showed in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC50 values of 13.2, 10.9 and 13.9 microg/mL.

摘要

从一株海洋来源的曲霉属真菌的全发酵液提取物中分离出了四种具有细胞毒性的半萜类化合物，即托酚酮A - D。通过各种二维核磁共振技术确定了这些半萜类化合物的结构。使用改良的莫舍尔方法确定了托酚酮A的绝对构型。托酚酮A - C含有一个有趣的取代2,4,6 - 环庚三烯（托酚酮）环，推测该环是由托酚酮D通过氧化扩环形成的。托酚酮A、B和C对人结肠癌（HCT - 116）显示出体外细胞毒性，IC50值分别为13.2、10.9和13.9微克/毫升。