Dahlén G, Berg K, Gillnäs T, Ericson C
Clin Genet. 1975 Apr;7(4):334-41. doi: 10.1111/j.1399-0004.1975.tb00338.x.
A strong, positive association (P smaller than 0.0001) was found between the presence in serum of pre-beta1-lipoprotein upon electrophoresis in 0.5% agarose and the Lp(a+) phenotype in a series of 103 males aged 50-52 years participating in a health control study and in a series of 58 patients with sustained myocardial infarction. Both lipiprotein phenomena were more prevalent in the 58 patients than in the 103 presumably healthy males. The lack of any significant difference between total cholesterol values in the patients and the controls, despite the higher frequency of phenotype Lp(a+) in the former group, argues against the suggestion by Walton et al. (1974) that the increased Lp(a+) frequency in patients with coronary artery disease may be caused by a general increase in the concentration of low density lipoproteins (LDL).
在一项健康对照研究中的103名年龄在50 - 52岁的男性以及58名持续性心肌梗死患者中，发现0.5%琼脂糖电泳时血清中前β1 - 脂蛋白的存在与Lp(a+)表型之间存在强烈的正相关（P小于0.0001）。这两种脂蛋白现象在58名患者中比在103名可能健康的男性中更为普遍。尽管前一组中Lp(a+)表型的频率较高，但患者和对照组的总胆固醇值之间没有任何显著差异，这与Walton等人（1974年）的观点相悖，即冠状动脉疾病患者中Lp(a+)频率增加可能是由于低密度脂蛋白（LDL）浓度普遍升高所致。
