Postle A D, Darmady J M, Siggers D C
Clin Genet. 1978 Feb;13(2):233-6. doi: 10.1111/j.1399-0004.1978.tb04255.x.
The presence or absence of a double pre-beta lipoprotein (pre-beta 1+ or pre-beta 1-) peak on agarose gel electrophoresis was recorded in: a) 77 survivors of myocardial infarction, b) their first-degree relatives, and c) 148 controls. Thirty-nine percent of myocardial infarction survivors and 24% of controls had pre-beta 1+ (P less than 0.05). The segregation of pre-beta 1+ in the families of myocardial infarction survivors was consistent with autosomal dominant inheritance. In the control group, fasting serum cholesterol and triglyceride values were higher in the pre beta 1+ subjects, but the differences were not significant. We conclude that the presence of double pre-beta lipoprotein peak on electrophoresis is associated with an increased risk of myocardial infarction.
在以下人群中记录了琼脂糖凝胶电泳上双前β脂蛋白（前β1+或前β1-）峰的有无：a）77名心肌梗死幸存者，b）他们的一级亲属，以及c）148名对照者。39%的心肌梗死幸存者和24%的对照者有前β1+（P<0.05）。心肌梗死幸存者家族中前β1+的分离符合常染色体显性遗传。在对照组中，前β1+受试者的空腹血清胆固醇和甘油三酯值较高，但差异不显著。我们得出结论，电泳上双前β脂蛋白峰的存在与心肌梗死风险增加有关。
