Choukroun Joseph, Diss Antoine, Simonpieri Alain, Girard Marie-Odile, Schoeffler Christian, Dohan Steve L, Dohan Anthony J J, Mouhyi Jaafar, Dohan David M
Pain Clinic Center, Nice, France.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Mar;101(3):e56-60. doi: 10.1016/j.tripleo.2005.07.011.
Platelet-rich fibrin (PRF) belongs to a new generation of platelet concentrates, with simplified processing and without biochemical blood handling. In this fourth article, investigation is made into the previously evaluated biology of PRF with the first established clinical results, to determine the potential fields of application for this biomaterial. The reasoning is structured around 4 fundamental events of cicatrization, namely, angiogenesis, immune control, circulating stem cells trapping, and wound-covering epithelialization. All of the known clinical applications of PRF highlight an accelerated tissue cicatrization due to the development of effective neovascularization, accelerated wound closing with fast cicatricial tissue remodelling, and nearly total absence of infectious events. This initial research therefore makes it possible to plan several future PRF applications, including plastic and bone surgery, provided that the real effects are evaluated both impartially and rigorously.
富血小板纤维蛋白（PRF）属于新一代血小板浓缩物，其加工过程简化，无需对血液进行生化处理。在这第四篇文章中，结合首次确立的临床结果，对之前评估的PRF生物学特性进行研究，以确定这种生物材料的潜在应用领域。推理围绕愈合的4个基本过程展开，即血管生成、免疫控制、循环干细胞捕获和伤口覆盖上皮形成。PRF所有已知的临床应用均表明，由于有效的新血管形成，组织愈合加速，伤口快速闭合，瘢痕组织重塑迅速，且几乎完全没有感染事件。因此，这项初步研究使得规划未来PRF的多种应用成为可能，包括整形手术和骨外科手术，前提是要公正且严格地评估其实际效果。
