Viru A
Department of Sports Physiology, Tartu University, Estonia/U.S.S.R.
Exp Clin Endocrinol. 1991 Mar;97(1):13-28. doi: 10.1055/s-0029-1211033.
Results of various studies suggest the existence of regulatory factors controlling the interaction of hormone with receptor and the postreceptor processes. Hence, the hormone effect is actualized through private and attending regulations. The first consists in the induction of specific effects of the hormone in target tissues. The attending regulation is realized as: 1) modulating regulation, acting on the state and number of cellular receptors, 2) metabolic regulation, acting via the other receptors on the cellular metabolism and changing in such a way the actualization of private regulation, 3) regulation of protein synthesis, acting on the synthesis of structure and enzyme proteins, participating in the actualization of private regulation. In physiologic meaning the modulating regulation consists in guaranteeing (to maintain the accordance between numbers of binding sites and acting signal molecules), homeostatic (to maintain the hormone balance through the alterations on the receptor level) and stress (to facilitate the regulatory effects through changes on receptor or postreceptor levels) regulations.
各项研究结果表明存在控制激素与受体相互作用及受体后过程的调节因子。因此，激素效应是通过自身调节和伴随调节实现的。前者在于诱导激素在靶组织中的特定效应。伴随调节表现为：1）调节性调节，作用于细胞受体的状态和数量；2）代谢调节，通过其他受体作用于细胞代谢，并以这种方式改变自身调节的实现；3）蛋白质合成调节，作用于结构蛋白和酶蛋白的合成，参与自身调节的实现。从生理意义上讲，调节性调节包括保证性（维持结合位点数量与作用信号分子数量之间的一致性）、稳态性（通过受体水平的改变维持激素平衡）和应激性（通过受体或受体后水平的变化促进调节效应）调节。
