Lennon A M, Pfeffer M, Buchalla W, Becker K, Lennon S, Attin T
Department of Operative Dentistry, Preventive Dentistry and Periodontology, University of Göttingen, Göttingen, Germany.
Caries Res. 2006;40(2):154-7. doi: 10.1159/000091063.
The aim of this study was to determine whether a tooth cream containing casein/calcium phosphate (CasCP) protects enamel against erosion. Sixty bovine enamel specimens were prepared for profilometry and distributed into five groups. Specimens were rinsed with artificial saliva interrupted by 1% citric acid (pH 2.3) for 30 s 6 times daily for 14 days. Group 1 (n=12) was not treated (control); in group 2 (n=12) CasCP was applied for 120 s twice daily; in group 3 (n=12) 250 ppm fluoride as NaF was applied for 120 s twice daily; in group 4 (n=12) CasCP was applied for 120 s, then 250 ppm fluoride for 120 s twice daily, and in group 5 (n=12) amine fluoride (AmF) gel (12,500 ppm fluoride) was applied for 120 s twice daily. Differences between groups with respect to erosive enamel loss (profilometrically determined depth after 7 and 14 days) were tested by the Mann-Whitney test (alpha=0.05). After 7/14 days' erosive cycling, specimens treated with AmF gel showed significantly less enamel loss (18.5/35.5 microm; medians) than those treated with CasCP (25.5/46.9 microm), 250 ppm fluoride (25.0/ 40.9 microm), CasCP and 250 ppm fluoride (23.9/47.4 microm) or with no treatment (26.3/49.8 microm). It is concluded that highly fluoridated acidic AmF gel can protect enamel against erosion while CasCP, 250 ppm fluoride or a combination of CasCP and 250 ppm fluoride provide little protection.
本研究的目的是确定一种含有酪蛋白/磷酸钙（CasCP）的牙膏是否能保护牙釉质免受侵蚀。制备了60个牛牙釉质标本用于轮廓测定，并分为五组。标本用人工唾液冲洗，期间每隔一段时间用1%柠檬酸（pH 2.3）冲洗30秒，每天6次，共14天。第1组（n = 12）不做处理（对照组）；第2组（n = 12）每天两次涂抹CasCP 120秒；第3组（n = 12）每天两次涂抹250 ppm的氟化钠（NaF）120秒；第4组（n = 12）先涂抹CasCP 120秒，然后每天两次涂抹250 ppm的氟化钠120秒；第5组（n = 12）每天两次涂抹胺氟（AmF）凝胶（12,500 ppm氟化物）120秒。通过曼-惠特尼检验（α = 0.05）测试各组之间牙釉质侵蚀损失（7天和14天后轮廓测定的深度）的差异。经过7/14天的侵蚀循环后，用AmF凝胶处理的标本显示出牙釉质损失（中位数为18.5/35.5微米）明显少于用CasCP（25.5/46.9微米）、用含250 ppm氟化物（25.0/40.9微米）、用CasCP和250 ppm氟化物（23.9/47.4微米）处理的标本或未处理的标本（26.3/49.8微米）。结论是，高氟酸性AmF凝胶可以保护牙釉质免受侵蚀，而CasCP、250 ppm氟化物或CasCP与250 ppm氟化物的组合提供的保护很少。
