Taylor Benjamin, Rehm Jurgen
Centre for Addiction and Mental Health, Toronto, Canada.
Dig Dis. 2005;23(3-4):177-80. doi: 10.1159/000090164.
BACKGROUND/AIMS: Alcohol drinking is responsible for a number of gastrointestinal diseases and cancers. Although heavy drinking episodes and chronic drinking are well linked to mechanisms of disease, moderate alcohol consumption and its effects are less well known. This review attempts to fill a gap in the literature surrounding moderate alcohol consumption.
A systematic review of the English literature using PubMed was used.
A dose-response risk relationship exists between alcohol consumption and digestive disease risk. Acetaldehyde is the main factor in alcohol-related damage in moderate alcohol consumption and acts through numerous methods to exert damaging effects.
Zero alcohol intake is recommended for lowest risk of alcohol-related digestive tract diseases and conditions. However, given the lowest overall mortality is associated with moderate drinking, moderate drinking with no bingeing episodes is recommended.
背景/目的：饮酒会引发多种胃肠道疾病和癌症。尽管大量饮酒和长期饮酒与疾病机制密切相关，但适度饮酒及其影响却鲜为人知。本综述旨在填补围绕适度饮酒的文献空白。
使用PubMed对英文文献进行系统综述。
饮酒与消化系统疾病风险之间存在剂量反应风险关系。乙醛是适度饮酒中酒精相关损伤的主要因素，通过多种方式发挥破坏作用。
为使酒精相关消化道疾病和病症的风险最低，建议零酒精摄入。然而，鉴于总体死亡率最低与适度饮酒相关，建议适度饮酒且无暴饮情况。
