Cooper M L, Hansbrough J F, Spielvogel R L, Cohen R, Bartel R L, Naughton G
Department of Surgery, University of California, San Diego Medical Center 92103.
Biomaterials. 1991 Mar;12(2):243-8. doi: 10.1016/0142-9612(91)90207-q.
The design of a skin-substitute must address the need for a dermal component, as this mesenchymally-derived tissue is important in maintaining the integrity and function of skin. An in vivo study was undertaken to assess the use of two biodegradable meshes, polyglycolic acid and polyglactin-910, as carriers for cultured human fibroblasts in a living dermal replacement. The consistent vascularization and epithelialization of these grafts placed on athymic mice showed that this has potential in re-creating the dermis in a skin-substitute.
