聚L-乳酸可植入网片的生物降解性与生物相容性
Biodegradation and Biocompatibility of Poly L-lactic Acid Implantable Mesh.
作者信息
Yoon Sang-Don, Kwon Young-Sam, Lee Kyu-Sung
机构信息
Department of Medical Device Management & Research, SAIHST, Sungkyunkwan University, Seoul, Korea.
Department of Veterinary Surgery, College of Veterinary Medicine, Kyungpook National University, Daegu, Korea.
出版信息
Int Neurourol J. 2017 Apr;21(Suppl 1):S48-54. doi: 10.5213/inj.1734882.441. Epub 2017 Apr 21.
PURPOSE
The purpose of this study was to evaluate the biodegradation and biocompatibility of poly L-lactic acid (PLLA) implantable mesh under and conditions.
METHODS
PLLA mesh was examined for changes in weight and tensile strength. The histology of the tissue around the PLLA implant was also evaluated.
RESULTS
The weight and tensile strength of the PLLA prosthesis was stable for 180 days. In addition, the surface of the PLLA mesh was not digested under or conditions as determined by scanning electron microscope. Histologically, there were no significant changes in the diameters of implanted PLLA mesh and subtype fibers over the course of 180 days. Likewise, there were no significant changes in the number of inflammatory and mast cells after 180 days, nor was there an increase in the percentage of collagen surrounding the PLLA mesh.
CONCLUSIONS
The results indicate that PLLA prostheses have good rigidity and biocompatibility and .
目的
本研究的目的是评估聚L-乳酸（PLLA）可植入网片在[具体条件1]和[具体条件2]条件下的生物降解性和生物相容性。
方法
检测PLLA网片的重量和拉伸强度变化。还评估了PLLA植入物周围组织的组织学情况。
结果
PLLA假体的重量和拉伸强度在180天内保持稳定。此外，通过扫描电子显微镜测定，在[具体条件1]或[具体条件2]条件下，PLLA网片的表面未被消化。组织学上，在180天的过程中，植入的PLLA网片和亚型纤维的直径没有显著变化。同样，180天后炎症细胞和肥大细胞的数量没有显著变化，PLLA网片周围的胶原蛋白百分比也没有增加。
结论
结果表明，PLLA假体在[具体条件1]和[具体条件2]下具有良好的刚性和生物相容性。
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