玻璃体腔注射曲安奈德联合维替泊芬光动力疗法治疗视网膜血管瘤样增生
Retinal angiomatous proliferation treated by intravitreal triamcinolone and photodynamic therapy with verteporfin.
作者信息
Nicolò Massimo, Ghiglione Davidina, Lai Silvio, Calabria Giovanni
机构信息
Dipartimento di Neuroscienze, Oftalmologia e Genetica, Sezione di Clinica Oculistica, Università di Genova, Osp. San Martino, Pad. 9, piano terra stanza 13. Largo R. Benzi 10, 16132, Genova, Italy.
出版信息
Graefes Arch Clin Exp Ophthalmol. 2006 Oct;244(10):1336-8. doi: 10.1007/s00417-006-0306-6. Epub 2006 Mar 8.
PURPOSE
To examine combined treatment of intravitreal triamcinolone acetonide (IVT) and photodynamic therapy (PDT) for retinal angiomatous proliferation (RAP).
METHODS
Ten eyes of eight consecutive patients with RAP underwent a single injection (about 20 mg) of IVT followed 1 month later by PDT. Best-corrected visual acuity (BCVA) was measured by standardized protocol refraction.
RESULTS
Median BCVA was 20/160, 20/64, 20/98, 20/89, 20/89, 20/125 at baseline and 1, 3, 6, 9 and 12 months, respectively. Of ten eyes, six (60%) improved BCVA of at least 3 lines at 1, 3, 6 and 9 months. Four (40%) eyes improved BCVA of at least 3 lines at 12 months. Three eyes (30%) lost >3 lines at 12 months. In all patients intraocular pressure was well controlled. No endophthalmitis, retinal detachment or vitreous haemorrhage developed.
CONCLUSIONS
Improvement of BCVA suggests that combination treatment with IVT and PDT for RAP merits further investigation.
目的
研究玻璃体内注射曲安奈德（IVT）联合光动力疗法（PDT）治疗视网膜血管瘤样增殖（RAP）的效果。
方法
连续8例RAP患者的10只眼接受单次IVT注射（约20mg），1个月后进行PDT治疗。采用标准化验光方案测量最佳矫正视力（BCVA）。
结果
基线时及1、3、6、9和12个月时的BCVA中位数分别为20/160、20/64、20/98、20/89、20/89、20/125。10只眼中，6只眼（60%）在1、3、6和9个月时BCVA至少提高了3行。4只眼（40%）在12个月时BCVA至少提高了3行。3只眼（30%）在12个月时视力下降超过3行。所有患者的眼压均得到良好控制。未发生眼内炎、视网膜脱离或玻璃体出血。
结论
BCVA的改善表明，IVT联合PDT治疗RAP值得进一步研究。
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