Subramoniam A, Husain R, Seth P K
Industrial Toxicology Research Centre, Lucknow, India.
Toxicol Lett. 1991 Aug;57(3):245-50. doi: 10.1016/0378-4274(91)90198-f.
Oral administration of a single dose of dibutyltin dilaurate (DBTL, 80 mg/kg body wt.), 2 or 24 h after treatment, caused no significant change in the levels of diacylglycerol and phosphoinositides in rat cerebrum (forebrain), whereas daily administration of DBTL (40 or 80 mg/kg body wt.) for 3 days (24 h after the final treatment) decreased the levels of diacylglycerol and phosphoinositides (phosphatidylinositol, phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate) in a concentration-dependent manner without influencing the levels of phosphatidylcholine in rat cerebrum. These studies indicate impairment of the phosphoinositide messenger system in rat cerebrum following repeated exposure to DBTL.
在治疗后2小时或24小时口服单剂量二月桂酸二丁基锡（DBTL，80毫克/千克体重），大鼠大脑（前脑）中的二酰基甘油和磷酸肌醇水平没有显著变化，而连续3天每日给予DBTL（40或80毫克/千克体重）（最后一次治疗后24小时），二酰基甘油和磷酸肌醇（磷脂酰肌醇、磷脂酰肌醇4-磷酸和磷脂酰肌醇4,5-二磷酸）水平呈浓度依赖性降低，且不影响大鼠大脑中磷脂酰胆碱的水平。这些研究表明，反复接触DBTL后大鼠大脑中的磷酸肌醇信使系统受损。
