Khaliq M A, Husain R, Seth P K, Srivastava S P
Industrial Toxicology Research Center, Lucknow, India.
Toxicol Lett. 1991 Feb;55(2):179-83. doi: 10.1016/0378-4274(91)90132-p.
Administration of dibutyltin dilaurate (DBTL; 0, 20 or 40 mg/kg body wt.) by gavage to rats for 3 consecutive days produced a significant increase in polyamine levels in selected brain areas. At the higher dose of DBTL (40 mg/kg) spermidine levels were raised in pons-medulla, hypothalamus and frontal cortex while spermine levels increased in pons-medulla, hippocampus and frontal cortex regions. At the lower dose (20 mg/kg) only a slight increase in polyamine levels occurred. The observed induction in regional brain polyamines in DBTL-treated rats may lead to disturbances in synaptic function and further enhance its neurotoxic potential.
连续3天经口灌胃给予大鼠二月桂酸二丁基锡（DBTL；0、20或40毫克/千克体重）后，选定脑区的多胺水平显著升高。在较高剂量的DBTL（40毫克/千克）下，脑桥延髓、下丘脑和额叶皮质中的亚精胺水平升高，而脑桥延髓、海马体和额叶皮质区域中的精胺水平增加。在较低剂量（20毫克/千克）下，多胺水平仅略有增加。在DBTL处理的大鼠中观察到的区域性脑多胺诱导可能导致突触功能紊乱，并进一步增强其神经毒性潜力。
