Bock Oliver, Schmid-Ott Gerhard, Malewski Peter, Mrowietz Ulrich
Primary Health Care Center, Hälsan 2, Fabriksgatan 17, 55 185, Jonkoping , Sweden.
Arch Dermatol Res. 2006 Apr;297(10):433-8. doi: 10.1007/s00403-006-0651-7. Epub 2006 Mar 10.
Keloid and hypertrophic scarring represent chronic disfiguring dermatoses with a high resistance to therapy. The aim of our study was to assess for the first time the quality of life of patients with hypertrophic scars and keloids, because they suffer from quality of life impairment as much as patients with other chronic skin diseases. An item-pool was created modifying and supplementing the items of the Questionnaire on Experience with Skin Complaints. This questionnaire was distributed to 100 outpatients with keloids and hypertrophic scars. A factor analysis was used to identify the underlying dimensions. Two scales (psychological and physical impairment) of the questionnaire with nine and five items, respectively, were established. Test-retest reliability of the questionnaire was excellent (corr > 0.9). Good validity was suggested by the correlation of physical impairment with pain (P < or = 0.001), pruritus (P < 0.001), and the amount of restriction of mobility (P < 0.001). The psychological scale was associated with pain and restriction of mobility, although the correlations were lower. This study demonstrates for the first time an impairment of quality of life in a large group of patients with keloid and hypertrophic scarring.
瘢痕疙瘩和增生性瘢痕是对治疗具有高度抗性的慢性毁容性皮肤病。我们研究的目的是首次评估增生性瘢痕和瘢痕疙瘩患者的生活质量，因为他们与其他慢性皮肤病患者一样，生活质量受到损害。通过修改和补充皮肤问题体验问卷的项目创建了一个项目池。该问卷被分发给100名患有瘢痕疙瘩和增生性瘢痕的门诊患者。采用因子分析来确定潜在维度。分别建立了该问卷的两个量表（心理和身体损害），各包含9项和5项。问卷的重测信度极佳（相关性>0.9）。身体损害与疼痛（P≤0.001）、瘙痒（P<0.001）以及活动受限程度（P<0.001）之间的相关性表明该问卷具有良好的效度。心理量表与疼痛和活动受限相关，尽管相关性较低。这项研究首次证明了一大群瘢痕疙瘩和增生性瘢痕患者的生活质量受损。
