Liao Can, Wei Jiaxue, Li Qiuming, Li Lixian, Li Jian, Li Dongzhi
Prenatal Diagnostic Center, Guangzhou Maternal and Neonatal Hospital, Guangzhou Medical College, Guangzhou, Guangdong, China.
Int J Gynaecol Obstet. 2006 Apr;93(1):13-7. doi: 10.1016/j.ijgo.2006.01.005. Epub 2006 Mar 10.
To assess the efficacy and safety of diagnostic cordocentesis.
Between January 1991 and May 2004, 2,010 cordocentesis were performed in the outpatient setting in 2,010 women with singleton pregnancies. A fixed needle guide and a 22-gauge percutaneous needle were used and no more than 2 attempts were allowed at 1 visit. In most cases, the umbilical vein was the target vessel. The results of each procedure and pregnancy outcomes were recorded and analyzed.
The most frequent indication for cordocentesis was risk of severe thalassemia (59.0%), followed by a need for rapid karyotyping (30.0%). Most of the procedures (97%) were performed in the free cord loop and the remaining at the cord insertion. The overall success rate was 98.4%, with 80.0% of the successful procedures performed at the first needle insertion and the remaining 20% at the second insertion. Transient bleeding was observed at the puncture site in 19.8% of cases and transient fetal bradycardia in 4.9% of cases. The total fetal loss and cordocentesis-related loss rates within 2 weeks of cordocentesis were 2.7% and 1.0%, respectively, before 24 weeks of gestation and 1.9% and 0.8% after 24 weeks. The other obstetric complications were unremarkable.
Cordocentesis is a simple, safe, and reliable procedure for prenatal diagnosis.
评估诊断性脐带穿刺术的有效性和安全性。
1991年1月至2004年5月期间，对2010名单胎妊娠女性在门诊进行了2010次脐带穿刺术。使用固定针引导器和22号经皮穿刺针，每次就诊允许不超过2次穿刺尝试。在大多数情况下，脐静脉是目标血管。记录并分析每次操作的结果和妊娠结局。
脐带穿刺术最常见的指征是重型地中海贫血风险（59.0%），其次是需要快速进行核型分析（30.0%）。大多数操作（97%）在游离脐带环处进行，其余在脐带附着处进行。总体成功率为98.4%，80.0%的成功操作在首次穿刺时完成，其余20%在第二次穿刺时完成。19.8%的病例在穿刺部位观察到短暂出血，4.9%的病例出现短暂胎儿心动过缓。在妊娠24周前，脐带穿刺术后2周内的总胎儿丢失率和与脐带穿刺术相关的丢失率分别为2.7%和1.0%，24周后分别为1.9%和0.8%。其他产科并发症不明显。
脐带穿刺术是一种简单、安全且可靠的产前诊断方法。
