Adler S P
Department of Pediatrics, Medical College of Virginia, Richmond.
Pediatr Infect Dis J. 1991 Aug;10(8):584-90.
To account for the wide variations in the prevalence of cytomegalovirus infections among day-care centers we serially tested 309 children at three day-care centers for 3 years. Based on the DNA restriction endonuclease pattern of each isolate, the rate of infection for children differed significantly (P less than 0.001) among centers: at Center 1, 50% (46 of 93) of children acquired cytomegalovirus in day care; at Center 2, 62% (64 of 104); and at Center 3, 25% (21 of 84). Infection rates were associated with the number of infants enrolled, and half or more of infected children were younger than 24 months of age. Six of 7 new isolates were introduced by children 18 months of age. Based on DNA patterns the prevalent isolates at Centers 1 and 2, although different, were shed for an average of 22 and 23 months, respectively, compared with an average of 15 months for other isolates (P less than 0.001). Reinfections with the prevalent isolates were observed for 2 of 34 children tested. The most important factors affecting day-care center transmission are the number of infants enrolled and prolonged viral shedding, possibly enhanced by reinfection.
为了解日托中心之间巨细胞病毒感染患病率的广泛差异，我们对三个日托中心的309名儿童进行了连续3年的检测。根据每个分离株的DNA限制性内切酶模式，各中心儿童的感染率差异显著（P<0.001）：在中心1，50%（93名中的46名）儿童在日托期间感染了巨细胞病毒；在中心2，62%（104名中的64名）；在中心3，25%（84名中的21名）。感染率与入托婴儿数量有关，半数或更多受感染儿童年龄小于24个月。7株新分离株中有6株是由18个月大的儿童引入的。根据DNA模式，中心1和中心2的流行分离株虽然不同，但分别平均排毒22个月和23个月，而其他分离株平均排毒15个月（P<0.001）。在接受检测的34名儿童中，有2名再次感染了流行分离株。影响日托中心传播的最重要因素是入托婴儿数量和病毒长期排毒，再次感染可能会加剧这种情况。
