Walhovd Kristine B, Fjell Anders M, Dale Anders M, Fischl Bruce, Quinn Brian T, Makris Nikos, Salat David, Reinvang Ivar
University of Oslo, Department of Psychology, POB 1094 Blindern, 0317 Oslo, Norway.
Neuroimage. 2006 Jul 1;31(3):1343-51. doi: 10.1016/j.neuroimage.2006.01.011. Epub 2006 Mar 15.
The aim of this study was to determine the role of regional cortical thickness in recall of verbal material over an extended time period. MRI scans of healthy adults of varying ages were obtained. Two scans were averaged per person to achieve high spatial resolution, and a semi-automated method for continuous measurement of thickness across the entire cortical mantle was employed. Verbal memory tests assessing recall after 5 min, 30 min, and a mean interval of 83 days were administered. A general linear model (GLM) of the effects of thickness at each vertex on the different memory indices was computed, controlling for gender, age, IQ, and intracranial volume. These analyses were repeated with hippocampal volume as an additional variable to be controlled for, to assess to which extent effects of cortical thickness were independent of hippocampal size. Minute effects of cortical thickness were observed with regard to shorter time intervals (5 and 30 min). However, even when controlling for the effects of hippocampal volume, higher recall across months was associated with thicker cortex of distinct areas including parts of the gyrus rectus, the middle frontal gyrus, the parieto-occipital sulcus and the lingual gyrus of both hemispheres. In addition, hemisphere-specific associations were found in parts of the right temporal and parietal lobe as well as parts of the left precuneus. This supports a unique and critical role of the thickness of distinct cortical areas in recall after months, more than after minutes.
本研究的目的是确定在较长时间段内区域皮质厚度在言语材料回忆中的作用。对不同年龄的健康成年人进行了磁共振成像（MRI）扫描。每人的两次扫描结果取平均值以获得高空间分辨率，并采用一种半自动方法对整个皮质表面的厚度进行连续测量。进行了言语记忆测试，评估5分钟、30分钟以及平均间隔83天后的回忆情况。计算每个顶点厚度对不同记忆指标影响的一般线性模型（GLM），同时控制性别、年龄、智商和颅内体积。以海马体体积作为另一个需要控制的变量重复这些分析，以评估皮质厚度的影响在多大程度上独立于海马体大小。在较短时间间隔（5分钟和30分钟）观察到皮质厚度的微小影响。然而，即使控制了海马体体积的影响，数月间更高的回忆与不同区域较厚的皮质相关，这些区域包括双侧直回的部分、额中回、顶枕沟和舌回。此外，在右侧颞叶和顶叶的部分区域以及左侧楔前叶的部分区域发现了半球特异性关联。这支持了不同皮质区域厚度在数月后而非数分钟后的回忆中具有独特且关键的作用。
