真核生物DNA修复：透过酿酒酵母的洞察

Eukaryotic DNA repair: glimpses through the yeast Saccharomyces cerevisiae.

作者信息

Friedberg E C

机构信息

Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235.

出版信息

Bioessays. 1991 Jun;13(6):295-302. doi: 10.1002/bies.950130607.

DOI:10.1002/bies.950130607

PMID:1654051

Abstract

Eukaryotic cells are able to mount several genetically complex cellular responses to DNA damage. The yeast Saccharomyces cerevisiae is a genetically well characterized organism that is also amenable to molecular and biochemical studies. Hence, this organism has provided a useful and informative model for dissecting the biochemistry and molecular biology of DNA repair in eukaryotes.

摘要

真核细胞能够对DNA损伤产生几种基因复杂的细胞反应。酿酒酵母是一种遗传特征明确的生物体，也适合进行分子和生化研究。因此，这种生物体为剖析真核生物DNA修复的生物化学和分子生物学提供了一个有用且信息丰富的模型。