Aijaz Naghma J, Flaherty Evelyn M, Preston Thomas, Bracken Stacey Storch, Lane Andrew H, Wilson Thomas A
Department of Pediatric Endocrinology, State University of New York, Stony Brook, NY, USA.
BMC Endocr Disord. 2006 Mar 20;6:2. doi: 10.1186/1472-6823-6-2.
Although thyroxin therapy clearly is beneficial to children with frank hypothyroidism there is little data on the effects of thyroxin in children with compensated or subclinical hypothyroidism. The objective of this study was to determine the effect of thyroxin therapy on cognitive function in children with compensated hypothyroidism. The hypothesis was that thyroxin therapy would change neuropsychological function.
Eleven patients with a history of sub clinical hypothyroidism entered the study. At the start of the study, six out of the 11 were on thyroxin therapy, while 5 were off therapy. All patients underwent a battery of neuropsychological testing and thyroid function tests at the start of study. Based on the results of thyroid function tests, two of the 5 patients who were off thyroxin were started back on thyroxin. All of the 6 patients who were on thyroxin were taken off thyroxin. All patients then underwent repeat neuropsychological testing and thyroid functions after an average of 91 days.
Thyroxin therapy could not be shown to have an effect on neuropsychological function in this short term study. Our patients had attention problems as compared to the normal population. No significant differences were found between our subjects and normal population standards in verbal processing, visual processing, motor speed/coordination and achievement.
In this small, short term study, thyroxin therapy could not be shown to affect neuropsychological function in children with compensated hypothyroidism. These children may have attention problems but appear to have normal verbal and visual processing, motor speed/coordination and achievement.
尽管甲状腺素疗法对明显甲状腺功能减退的儿童显然有益，但关于甲状腺素对代偿性或亚临床甲状腺功能减退儿童的影响的数据却很少。本研究的目的是确定甲状腺素疗法对代偿性甲状腺功能减退儿童认知功能的影响。假设是甲状腺素疗法会改变神经心理功能。
11名有亚临床甲状腺功能减退病史的患者进入该研究。在研究开始时，11名患者中有6名正在接受甲状腺素治疗，而5名未接受治疗。所有患者在研究开始时均接受了一系列神经心理测试和甲状腺功能测试。根据甲状腺功能测试结果，5名未服用甲状腺素的患者中有2名重新开始服用甲状腺素。6名正在服用甲状腺素的患者均停止服用甲状腺素。所有患者在平均91天后再次接受神经心理测试和甲状腺功能检查。
在这项短期研究中，未显示甲状腺素疗法对神经心理功能有影响。与正常人群相比，我们的患者存在注意力问题。在言语处理、视觉处理、运动速度/协调性和成绩方面，我们的受试者与正常人群标准之间未发现显著差异。
在这项小型短期研究中，未显示甲状腺素疗法会影响代偿性甲状腺功能减退儿童的神经心理功能。这些儿童可能存在注意力问题，但在言语和视觉处理、运动速度/协调性及成绩方面似乎正常。
