环磷酸腺苷，一种细胞周期的非必需调节因子。
Cyclic AMP, a nonessential regulator of the cell cycle.
作者信息
Coffino P, Gray J W, Tomkins G M
出版信息
Proc Natl Acad Sci U S A. 1975 Mar;72(3):878-82. doi: 10.1073/pnas.72.3.878.
Abstract
Flow-microfluorimetric analysis has been carried out on populations of exponentially growing S49 mouse lymphoma cells treated with dibutyryl cyclic AMP. The drug produces a specific concentration-dependent block in the G-1 phase of the cell cycle while other phases of the cycle are not perceptibly altered. The cell cycle of a line of mutant cells lacking the cyclic AMP-dependent protein kinase is not affected by the drug. Since these mutant cells have been shown to maintain a normal cell cycle, even in the presence of high levels of cyclic AMP, periodic fluctuations in the levels of the cyclic nucleotide cannot be required for or determine progression through the cell cycle.
摘要
已对用二丁酰环磷腺苷（dibutyryl cyclic AMP）处理的呈指数生长的S49小鼠淋巴瘤细胞群体进行了流式微量荧光分析。该药物在细胞周期的G-1期产生特定的浓度依赖性阻滞，而细胞周期的其他阶段未发生明显改变。缺乏环磷腺苷依赖性蛋白激酶的突变细胞系的细胞周期不受该药物影响。由于已证明这些突变细胞即使在存在高水平环磷腺苷的情况下仍能维持正常的细胞周期，因此细胞周期进程并不需要环核苷酸水平的周期性波动，也不受其决定。
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