尼日利亚阿布贾新诊断结核病患者的高钙血症
Hypercalcemia in patients with newly diagnosed tuberculosis in Abuja, Nigeria.
作者信息
Dosumu E A, Momoh J A
机构信息
Department of Medicine, National Hospital, Abuja, Nigeria.
出版信息
Can Respir J. 2006 Mar;13(2):83-7. doi: 10.1155/2006/407609.
BACKGROUND
The prevalence of hypercalcemia has not previously been determined in newly diagnosed tuberculosis (TB) patients in Nigeria.
OBJECTIVE
To determine the incidence of hypercalcemia in Nigerian patients with newly diagnosed TB before the commencement of anti-TB treatment.
METHODS
The present study is a prospective examination of consecutive patients with newly diagnosed TB confirmed by bacteriological and/or histological methods at the National Hospital (Abuja, Nigeria) from January 2004 to December 2004.
RESULTS
Of 120 patients (70 males and 50 females), 70 had pulmonary TB, 10 had pulmonary and pleural TB, 20 had pleural TB without radiographic evidence of lung involvement, 18 had various other forms of extrapulmonary TB and two had disseminated TB. The mean age of the patients was 38.3+/-12.0 years. The mean albumin-adjusted serum calcium concentration was 2.53+/-0.22 mmol/L. Hypercalcemia was present in 27.5% of the patients, but only 12% of these patients showed symptoms of hypercalcemia. The type of TB and, in the case of pulmonary TB, the extent of lung involvement, had no effect on the serum calcium concentration.
CONCLUSION
Hypercalcemia is not uncommon among Nigerian patients with newly diagnosed TB, but it is rarely symptomatic.
背景
此前尚未确定尼日利亚新诊断肺结核（TB）患者中高钙血症的患病率。
目的
确定尼日利亚新诊断TB患者在开始抗结核治疗前高钙血症的发生率。
方法
本研究是对2004年1月至2004年12月在尼日利亚阿布贾国家医院通过细菌学和/或组织学方法确诊的新诊断TB连续患者进行的前瞻性检查。
结果
120例患者（70例男性和50例女性）中，70例患有肺结核，10例患有肺结核和结核性胸膜炎，20例患有结核性胸膜炎但无肺部受累的影像学证据，18例患有其他各种肺外结核形式，2例患有播散性结核。患者的平均年龄为38.3±12.0岁。白蛋白校正后的血清钙平均浓度为2.53±0.22 mmol/L。27.5%的患者存在高钙血症，但这些患者中只有12%表现出高钙血症症状。TB类型以及肺结核患者的肺部受累程度对血清钙浓度没有影响。
结论
高钙血症在尼日利亚新诊断的TB患者中并不罕见，但很少有症状。
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