两名患乳腺伯基特淋巴瘤姐妹的近亲的免疫学观察。姐妹中的乳腺伯基特淋巴瘤。
Immunologic observations in close relatives of two sisters with mammary Burkitt's lymphoma. Mammary Burkitt's lymphoma in sisters.
作者信息
Poulsen L O, Christensen J H, Sørensen B, Ebbesen P, Pallesen G, Grunnet N
机构信息
Department of Internal Medicine and Hematology, Aalborg Hospital, Denmark.
出版信息
Cancer. 1991 Sep 1;68(5):1031-4. doi: 10.1002/1097-0142(19910901)68:5<1031::aid-cncr2820680521>3.0.co;2-s.
In a sibship of four sisters, two had Burkitt's lymphoma localized to the breast. Their pretreatment Epstein-Barr virus (EBV) serology were not examined. No EBV genome was demonstrated in the tumors using an in situ hybridization technique. The mother showed an abnormal antibody response to EBV infection consisting of elevated IgA and IgG antibody titers to viral capsid antigen (VCA) and high IgG antibody titer to early antigen. Furthermore, one of the two healthy sisters showed elevated IgG antibody titer to VCA. The EBV serology is mimicking the findings in female carriers of the X-linked lymphoproliferative syndrome.
在一个四姐妹的家庭中，有两人患局限性乳腺伯基特淋巴瘤。她们未接受治疗前的爱泼斯坦-巴尔病毒（EBV）血清学检查。使用原位杂交技术在肿瘤中未检测到EBV基因组。母亲对EBV感染表现出异常的抗体反应，包括针对病毒衣壳抗原（VCA）的IgA和IgG抗体滴度升高以及针对早期抗原的高IgG抗体滴度。此外，两个健康姐妹中的一人对VCA的IgG抗体滴度升高。EBV血清学表现类似于X连锁淋巴增殖综合征女性携带者的检查结果。
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