Wang Xiao-Hong, Aliyari Roghiyh, Li Wan-Xiang, Li Hong-Wei, Kim Kevin, Carthew Richard, Atkinson Peter, Ding Shou-Wei
Graduate Program for Microbiology, University of California, Riverside, CA 92521, USA.
Science. 2006 Apr 21;312(5772):452-4. doi: 10.1126/science.1125694. Epub 2006 Mar 23.
Innate immunity against bacterial and fungal pathogens is mediated by Toll and immune deficiency (Imd) pathways, but little is known about the antiviral response in Drosophila. Here, we demonstrate that an RNA interference pathway protects adult flies from infection by two evolutionarily diverse viruses. Our work also describes a molecular framework for the viral immunity, in which viral double-stranded RNA produced during infection acts as the pathogen trigger whereas Drosophila Dicer-2 and Argonaute-2 act as host sensor and effector, respectively. These findings establish a Drosophila model for studying the innate immunity against viruses in animals.
果蝇对细菌和真菌病原体的固有免疫由Toll和免疫缺陷（Imd）信号通路介导，但对其抗病毒反应却知之甚少。在此，我们证明RNA干扰途径可保护成年果蝇免受两种进化上不同的病毒感染。我们的研究还描述了病毒免疫的分子框架，其中感染期间产生的病毒双链RNA作为病原体触发因子，而果蝇Dicer-2和Argonaute-2分别作为宿主传感器和效应器。这些发现建立了一个用于研究动物对病毒固有免疫的果蝇模型。
