L 细胞中干扰素的差异产生和抗诱导原理。
Differential production of interferon and refractoriness inducing principle in L cells.
机构信息
Department of Medical Viral Oncology, Roswell Park, Memorial Institute, and the Graduate Faculty in Microbiology, State University of New York at Buffalo, Buffalo, New York 14203.
出版信息
Infect Immun. 1974 Nov;10(5):1057-61. doi: 10.1128/iai.10.5.1057-1061.1974.
The extracellular, acid-soluble cell products (EASCP) from Newcastle disease virus-infected L(929) cells contain both interferon, defined as antiviral activity, and refractoriness inducing principle, defined as an activity that inhibits interferon production. L cells pretreated with EASCP and then infected with Newcastle disease virus give rise to EASCP with decreased amounts of interferon but an increased ratio of refractoriness inducing principle activity to interferon activity in a dose related manner. The antiviral activity of an EASCP preparation is not dependent upon its refractoriness inducing principle level, but is entirely dependent on its interferon content. Our results provide additional evidence that interferon and refractoriness inducing principle are different biological entities and not polymorphic functions of the interferon molecule.
新城疫病毒感染的 L（929）细胞的细胞外、酸溶性细胞产物（EASCP）中含有干扰素和抗干扰素产生的致阻抑因子。EASCP 预处理的 L 细胞，再感染新城疫病毒，导致 EASCP 中干扰素含量降低，而致阻抑因子活性与干扰素活性的比值则呈剂量相关性增加。EASCP 制剂的抗病毒活性不依赖于其致阻抑因子的水平，而完全依赖于其干扰素含量。我们的结果进一步证明，干扰素和致阻抑因子是不同的生物学实体，而不是干扰素分子的多态性功能。
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