感染鼠巨细胞病毒的小鼠中干扰素和血清低反应性因子的产生。
Production of interferon and serum hyporeactivity factor in mice infected with murine cytomegalovirus.
作者信息
Tarr G C, Armstrong J A, Ho M
出版信息
Infect Immun. 1978 Mar;19(3):903-7. doi: 10.1128/iai.19.3.903-907.1978.
Abstract
Mice injected intraperitoneally with murine cytomegalovirus produced as many as 1,000 U of serum interferon. The response appeared biphasic, with maximum titers in the first phase detectable from 2 through 4 days after infection. A second phase peaked 10 days after infection. By carboxyhexyl-Sepharose affinity chromatography, the serum interferon behaved like lymphocyte interferon. The infected mice also produced substantial quantities of serum hyporeactivity factor (D.A. Stringfellow, E.R. Kern, D.K. Kelsey, and L.A. Glasgow, J. Infect. Dis. 135:540-551, 1977), although always in the presence of interferon. This factor was separated from the serum interferon by concanavalin A-Sepharose affinity chromatography.
摘要
经腹腔注射鼠巨细胞病毒的小鼠产生了多达1000单位的血清干扰素。这种反应呈双相性，在感染后2至4天的第一阶段可检测到最高滴度。第二阶段在感染后10天达到峰值。通过羧基己基-琼脂糖亲和层析，血清干扰素的表现类似于淋巴细胞干扰素。受感染的小鼠还产生了大量的血清低反应性因子（D.A. 斯特林费罗、E.R. 克恩、D.K. 凯尔西和L.A. 格拉斯哥，《传染病杂志》135:540 - 551, 1977），尽管总是在有干扰素存在的情况下。通过伴刀豆球蛋白A - 琼脂糖亲和层析将该因子与血清干扰素分离。
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2
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Virology. 1965 Mar;25:331-9. doi: 10.1016/0042-6822(65)90052-8.
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4
The interferon refractory state: in vivo and in vitro studies of its mechanism.干扰素难治性状态：其机制的体内和体外研究
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5
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