Henrotin Yves, Marty Marc, Mobasheri Ali
Bone and Cartilage Research Unit, Arthropôle Liège, University of Liège, Institute of Pathology, CHU Sart-Tilman, 4000 Liège, Belgium.
Rheumatology Department, Teaching Hospital H Mondor, Creteil, France.
Maturitas. 2014 Jul;78(3):184-7. doi: 10.1016/j.maturitas.2014.04.015. Epub 2014 May 1.
Chondroitin sulfate and glucosamine sulfate exert beneficial effects on the metabolism of in vitro models of cells derived from synovial joints: chondrocytes, synoviocytes and cells from subchondral bone, all of which are involved in osteoarthritis (OA). They increase type II collagen and proteoglycan synthesis in human articular chondrocytes and are able to reduce the production of some pro-inflammatory mediators and proteases, to reduce the cellular death process, and improve the anabolic/catabolic balance of the extracellular cartilage matrix (ECM). Clinical trials have reported a beneficial effect of chondroitin sulfate and glucosamine sulfate on pain and function. The structure-modifying effects of these compounds have been reported and analyzed in recent meta-analyses. The results for knee OA demonstrate a small but significant reduction in the rate of joint space narrowing. Chondroitin sulfate and glucosamine sulphate are recommended by several guidelines from international societies for the management of knee and hip OA, while others do not recommend these products or recommend only under condition. This comprehensive review clarifies the role of these compounds in the therapeutic arsenal for patients with knee OA.
硫酸软骨素和硫酸葡萄糖胺对源自滑膜关节的细胞（软骨细胞、滑膜细胞和软骨下骨细胞）的体外模型代谢具有有益作用，这些细胞均参与骨关节炎（OA）的发生。它们可增加人关节软骨细胞中II型胶原蛋白和蛋白聚糖的合成，并能够减少一些促炎介质和蛋白酶的产生，减少细胞死亡过程，改善细胞外软骨基质（ECM）的合成代谢/分解代谢平衡。临床试验报告了硫酸软骨素和硫酸葡萄糖胺对疼痛和功能的有益作用。这些化合物的结构改变作用已在最近的荟萃分析中得到报道和分析。膝关节OA的结果表明关节间隙狭窄率有小幅但显著的降低。国际社会的多项指南推荐硫酸软骨素和硫酸葡萄糖胺用于膝关节和髋关节OA的治疗，而其他指南则不推荐这些产品或仅在特定条件下推荐。这篇综述阐明了这些化合物在膝关节OA患者治疗手段中的作用。
