Hutchings D E, Brake S C, Banks A N, Nero T J, Dick L S, Zmitrovich A C
New York State Psychiatric Institute, Department of Developmental Psychobiology, NY 10032.
Neurotoxicol Teratol. 1991 Jul-Aug;13(4):413-6. doi: 10.1016/0892-0362(91)90090-j.
Either 15 or 30 mg/kg of delta-9-tetrahydrocannabinol (delta-9-THC) was administered to pregnant rats by gastric intubation from Day 2 through Day 22 of gestation. Pair-fed and nontreated groups served as controls and all treated and control litters were surrogate fostered at birth to untreated dams. When treated and control male and female offspring were tested for differences in auditory startle at 57-60 days of age, no effects were observed among any of the groups. These findings are compared with other neurobehavioral studies of adult offspring prenatally exposed to cannabis.
在妊娠第2天至第22天期间，通过胃管向怀孕大鼠给予15或30毫克/千克的Δ-9-四氢大麻酚（Δ-9-THC）。配对喂食组和未处理组作为对照组，所有处理组和对照组的幼崽在出生时都由未处理的母鼠代养。当对处理组和对照组的雄性和雌性后代在57至60日龄时进行听觉惊吓差异测试时，未在任何组中观察到影响。这些发现与其他关于产前暴露于大麻的成年后代的神经行为研究进行了比较。
