Safar Michel E, Czernichow Sébastien, Blacher Jacques
Hypertension and Cardiovascular Prevention Unit, Diagnosis Center, Hôtel-Dieu Hospital, 75181 Paris Cedex 04, France.
J Am Soc Nephrol. 2006 Apr;17(4 Suppl 2):S109-11. doi: 10.1681/ASN.2005121321.
Long-term follow-up studies have indicated that obesity is an independent predictor of cardiovascular risk in both genders. Increased arterial stiffness, as reflected by an increased pulse wave velocity, is significantly and independently associated with higher risk for cardiovascular morbidity and mortality. In recent years, it has been demonstrated that individuals with obesity are likely to have an increase in aortic stiffness, independent of BP level, ethnicity, and age. The pathophysiologic mechanisms that link abdominal adiposity to stiffening are not fully understood. This report focuses on the role of arterial stiffness in individuals with obesity and on the association between this hemodynamic feature and cardiovascular risk.
长期随访研究表明，肥胖是两性心血管风险的独立预测因素。脉搏波速度增加所反映的动脉僵硬度增加与心血管疾病发病率和死亡率的较高风险显著且独立相关。近年来，已证实肥胖个体的主动脉僵硬度可能增加，且与血压水平、种族和年龄无关。将腹部肥胖与动脉僵硬度联系起来的病理生理机制尚未完全明了。本报告重点关注动脉僵硬度在肥胖个体中的作用以及这一血流动力学特征与心血管风险之间的关联。
