Amouretti Michel, Le Pen Claude, Gaudin Anne-Françoise, Bommelaer Gilles, Frexinos Jacques, Ruszniewski Philippe, Poynard Thierry, Maurel Frédérique, Priol Gaël, El Hasnaoui Abdelkader
Service de Gastroentérologie, Hôpital du Haut-Lévêque, CHU de Bordeaux, Pessac.
Gastroenterol Clin Biol. 2006 Feb;30(2):241-6. doi: 10.1016/s0399-8320(06)73160-8.
To assess the impact of irritable bowel syndrome (IBS) on patient-reported health-related quality of life (HRQOL).
Two HRQOL instruments were administered by telephone interviews to a sample of 253 IBS French patients recruited from the general population. IBS was diagnosed according to the Manning, Rome I and Rome II criteria. Patients with organic diseases were excluded from the study. A generic instrument, the Short Form 36 (SF-36), and an IBS disease-specific instrument, the IBSQOL, were used.
Patients with IBS had statistically significant (P<0.05) lower scores for all SF-36 QOL domains compared with the general French population. Women (N=192) reported significantly (P<0.05) poorer HRQOL on both the SF-36 and the IBSQOL scores than men (N=61) for all domains except energy on the SF36 and the sleep on the IBSQOL. HRQOL deteriorated with time since onset of IBS symptoms for some domains such as diet. For both instruments, a positive correlation was observed between low scores and intensity of pain and discomfort. IBS patients with a predominance of diarrhea (N=72) exhibited significantly greater impairment of HRQOL in the emotional domain than IBS persons with constipation predominance (N=65) (P<or=0.05).
IBS has a significant impact on HRQOL of patients. In addition, specific characteristics such as gender, symptom severity and time since onset of symptoms are predictive of more impaired health-related quality of life.
评估肠易激综合征（IBS）对患者报告的健康相关生活质量（HRQOL）的影响。
通过电话访谈，对从普通人群中招募的253名法国IBS患者样本使用了两种HRQOL工具。IBS根据曼宁、罗马I和罗马II标准进行诊断。患有器质性疾病的患者被排除在研究之外。使用了一种通用工具，即简短健康调查问卷（SF - 36），以及一种IBS疾病特异性工具，即IBS生活质量量表（IBSQOL）。
与法国普通人群相比，IBS患者在所有SF - 36生活质量领域的得分在统计学上均显著较低（P<0.05）。在除SF - 36的精力领域和IBSQOL的睡眠领域外的所有领域，女性（N = 192）在SF - 36和IBSQOL得分上报告的HRQOL均显著低于男性（N = 61）（P<0.05）。对于某些领域，如饮食，自IBS症状发作以来，HRQOL随时间恶化。对于这两种工具，低分与疼痛和不适强度之间均观察到正相关。腹泻为主的IBS患者（N = 72）在情感领域的HRQOL受损程度明显大于便秘为主的IBS患者（N = 65）（P≤0.05）。
IBS对患者的HRQOL有显著影响。此外，性别、症状严重程度和症状发作时间等特定特征可预测健康相关生活质量受损更严重。
