Rahbani-Nobar Mohammad Bagher, Javadzadeh Alireza, Ghojazadeh Leila, Rafeey Mandana, Ghorbanihaghjo Amir
Department of Ophthalmology, Tabriz University of Medical Sciences, Tabriz, Iran.
Mol Vis. 2011 Jan 11;17:99-103.
The aim of this study was to evaluate the effect of Helicobacter pylori (H. pylori) treatment on remission of idiopathic central serous chorioretinopathy.
Twenty-five patients with idiopathic central serous chorioretinopathy (ICSCR) who were infected with H. pylori were treated with an anti-H. pylori treatment; another twenty-five patients with the same clinical presentations served as the control. Baseline examination and follow up visits at 2, 4, 6, 8, 12, and 16 weeks after the onset of treatment included visual acuity testing and subretinal fluid measurement. The difference between mean visual acuity at the end of 16 weeks and the time of subretinal fluid reabsorption was compared between the two groups.
Subretinal fluid reabsorption time was 9.28±3.20 weeks in the treatment group and 11.63±3.18 weeks in the control group, which was statistically significant (p=0.015). After 16 weeks, mean visual acuity improved to 0.003±0.01 (logMAR) in the treatment group and 0.004±0.02 (logMAR) in the control group. This improvement did not represent a statistically significant difference (p=0.97).
An anti-H. pylori treatment regimen is effective in the treatment of idiopathic central serous chorioretinopathy patients and anti-H. pylori treatment can provoke the faster reabsorption of subretinal fluid.
本研究旨在评估幽门螺杆菌（H. pylori）治疗对特发性中心性浆液性脉络膜视网膜病变缓解的影响。
25例感染幽门螺杆菌的特发性中心性浆液性脉络膜视网膜病变（ICSCR）患者接受抗幽门螺杆菌治疗；另外25例临床表现相同的患者作为对照。治疗开始后2、4、6、8、12和16周的基线检查及随访包括视力测试和视网膜下液测量。比较两组在16周结束时的平均视力与视网膜下液吸收时间的差异。
治疗组视网膜下液吸收时间为9.28±3.20周，对照组为11.63±3.18周，差异有统计学意义（p = 0.015）。16周后，治疗组平均视力提高到0.003±0.01（logMAR），对照组为0.004±0.02（logMAR）。这种改善无统计学差异（p = 0.97）。
抗幽门螺杆菌治疗方案对特发性中心性浆液性脉络膜视网膜病变患者有效，且抗幽门螺杆菌治疗可促使视网膜下液更快吸收。
