氧杂环丁烷类化合物对水痘-带状疱疹病毒的抗病毒活性。
Antiviral activity of oxetanocins against varicella-zoster virus.
作者信息
Sakuma T, Saijo M, Suzutani T, Yoshida I, Saito S, Kitagawa M, Hasegawa S, Azuma M
机构信息
Department of Microbiology, Asahikawa Medical College, Japan.
出版信息
Antimicrob Agents Chemother. 1991 Jul;35(7):1512-4. doi: 10.1128/AAC.35.7.1512.
Several new nucleosides with an oxetanosyl-N-glycoside group, named oxetanocins, were evaluated for their antiviral activities against varicella-zoster virus (VZV) in human embryo lung cells. 9-(2-deoxy-2-hydroxy-methyl-beta-D-erythro-oxetanosyl)guanine (OXT-G) and 9-(2-deoxy-2-hydroxymethyl-beta-D-erythro-oxetanosyl)-2- aminoadenine were effective against not only thymidine kinase-positive (TK+) VZV (YS strain) but also thymidine kinase-negative (TK-) VZV (YSR strain), whereas carbocyclic OXT-G was effective against TK+ VZV but not against TK- VZV. [3H]OXT-G was incorporated into TK+ VZV-infected cells and TK- VZV-infected cells more than into mock-infected cells and was converted into the triphosphate form.
几种带有氧杂环丁烷基-N-糖苷基团的新核苷，即氧杂环丁菌素，在人胚肺细胞中针对水痘带状疱疹病毒（VZV）的抗病毒活性进行了评估。9-(2-脱氧-2-羟甲基-β-D-赤型-氧杂环丁烷基)鸟嘌呤（OXT-G）和9-(2-脱氧-2-羟甲基-β-D-赤型-氧杂环丁烷基)-2-氨基腺嘌呤不仅对胸苷激酶阳性（TK+）的VZV（YS株）有效，而且对胸苷激酶阴性（TK-）的VZV（YSR株）也有效，而碳环OXT-G对TK+ VZV有效，但对TK- VZV无效。[3H]OXT-G被掺入TK+ VZV感染的细胞和TK- VZV感染的细胞中的量多于未感染的细胞，并转化为三磷酸形式。
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