对1-β-D-阿拉伯呋喃糖基-E-5-(2-溴乙烯基)尿嘧啶耐药的水痘-带状疱疹病毒毒株
Strains of varicella-zoster virus resistant to 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil.
作者信息
Sakuma T
出版信息
Antimicrob Agents Chemother. 1984 Jun;25(6):742-6. doi: 10.1128/AAC.25.6.742.
Abstract
Strains of varicella-zoster virus resistant to 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-araU) were isolated from varicella-zoster virus-infected Vero cells which were pulse-treated with 5-iododeoxyuridine or 5-bromodeoxyuridine or both and then treated with BV-araU. These BV-araU-resistant strains (BV-araUr) could not be isolated from varicella-zoster virus-infected cells treated with BV-araU alone and had reduced viral thymidine kinase activity. Two of five BV-araUr strains were also resistant to 5-iododeoxyuridine and 5-bromodeoxyuridine, whereas other BV-araUr strains were relatively susceptible to these drugs. All clones from the BV-araUr strain were susceptible to 1-beta-D-arabinofuranosylcytosine and phosphonoacetic acid, but 7 of 10 clones from the BV-araUr strain were resistant to 1-beta-D-arabinofuranosyladenine. The possible mechanisms of induction of BV-araU resistance are discussed.
摘要
从水痘带状疱疹病毒感染的Vero细胞中分离出对1-β-D-阿拉伯呋喃糖基-E-5-(2-溴乙烯基)尿嘧啶（BV-araU）耐药的水痘带状疱疹病毒毒株，这些细胞先用5-碘脱氧尿苷或5-溴脱氧尿苷或两者进行脉冲处理，然后用BV-araU处理。这些对BV-araU耐药的毒株（BV-araUr）无法从仅用BV-araU处理的水痘带状疱疹病毒感染细胞中分离出来，并且其病毒胸苷激酶活性降低。五个BV-araUr毒株中有两个也对5-碘脱氧尿苷和5-溴脱氧尿苷耐药，而其他BV-araUr毒株对这些药物相对敏感。来自BV-araUr毒株的所有克隆对1-β-D-阿拉伯呋喃糖基胞嘧啶和膦甲酸敏感，但来自BV-araUr毒株的10个克隆中有7个对1-β-D-阿拉伯呋喃糖基腺嘌呤耐药。本文讨论了诱导BV-araU耐药的可能机制。
相似文献
1
Strains of varicella-zoster virus resistant to 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil.对1-β-D-阿拉伯呋喃糖基-E-5-(2-溴乙烯基)尿嘧啶耐药的水痘-带状疱疹病毒毒株
Antimicrob Agents Chemother. 1984 Jun;25(6):742-6. doi: 10.1128/AAC.25.6.742.
2
Antiviral activity of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil against thymidine kinase negative strains of varicella-zoster virus.1-β-D-阿拉伯呋喃糖基-E-5-(2-溴乙烯基)尿嘧啶对水痘-带状疱疹病毒胸苷激酶阴性株的抗病毒活性。
Microbiol Immunol. 1993;37(11):877-82. doi: 10.1111/j.1348-0421.1993.tb01719.x.
3
4
Antiviral potencies of BV-araU and related nucleoside analogues against varicella-zoster virus in different cell lines.BV-araU及相关核苷类似物在不同细胞系中对水痘-带状疱疹病毒的抗病毒效力
Microbiol Immunol. 1990;34(11):959-65. doi: 10.1111/j.1348-0421.1990.tb01074.x.
5
Metabolic fate of [3H]1-beta-D-arabinofuranosyl-5-[(E)-2-bromovinyl]uracil in herpes simplex virus type 1-infected cells.[3H]1-β-D-阿拉伯呋喃糖基-5-[(E)-2-溴乙烯基]尿嘧啶在单纯疱疹病毒1型感染细胞中的代谢命运
Microbiol Immunol. 1997;41(12):957-64. doi: 10.1111/j.1348-0421.1997.tb01955.x.
6
In vitro drug combination of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil with anti-human immunodeficiency virus or anticancer nucleosides.1-β-D-阿拉伯呋喃糖基-E-5-(2-溴乙烯基)尿嘧啶与抗人类免疫缺陷病毒或抗癌核苷的体外药物联合应用
Antimicrob Agents Chemother. 1992 Jan;36(1):214-6. doi: 10.1128/AAC.36.1.214.
7
Inhibition of DNA synthesis in varicella-zoster virus-infected cells by BV-araU.BV-araU对水痘-带状疱疹病毒感染细胞中DNA合成的抑制作用。
Microbiol Immunol. 1991;35(2):139-45. doi: 10.1111/j.1348-0421.1991.tb01541.x.
8
In vitro and in vivo antiviral activity of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-araU) and related compounds.1-β-D-阿拉伯呋喃糖基-E-5-(2-溴乙烯基)尿嘧啶（BV-araU）及相关化合物的体外和体内抗病毒活性
Antiviral Res. 1984 Jun;4(3):135-41. doi: 10.1016/0166-3542(84)90013-5.
9
Oral bioavailability and anti-simian varicella virus efficacy of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-araU) in monkeys.1-β-D-阿拉伯呋喃糖基-E-5-(2-溴乙烯基)尿嘧啶（BV-araU）在猴体内的口服生物利用度及抗猴水痘病毒疗效
J Infect Dis. 1992 Apr;165(4):732-6. doi: 10.1093/infdis/165.4.732.
10
Effect of BV-araU and acyclovir on varicella-zoster virus replication with various length and timing of drug exposure.BV-araU和阿昔洛韦在不同药物暴露时长和时间下对水痘-带状疱疹病毒复制的影响。
Microbiol Immunol. 1994;38(2):109-15. doi: 10.1111/j.1348-0421.1994.tb01751.x.
引用本文的文献
1
Rapid phenotypic characterization method for herpes simplex virus and Varicella-Zoster virus thymidine kinases to screen for acyclovir-resistant viral infection.用于单纯疱疹病毒和水痘-带状疱疹病毒胸苷激酶的快速表型鉴定方法，以筛查对阿昔洛韦耐药的病毒感染。
J Clin Microbiol. 2000 May;38(5):1839-44. doi: 10.1128/JCM.38.5.1839-1844.2000.
2
Current pharmacological approaches to the therapy of varicella zoster virus infections: a guide to treatment.水痘带状疱疹病毒感染治疗的当前药理学方法：治疗指南
Drugs. 1999 Feb;57(2):187-206. doi: 10.2165/00003495-199957020-00005.
3
Analysis of phosphorylation pathways of antiherpesvirus nucleosides by varicella-zoster virus-specific enzymes.水痘-带状疱疹病毒特异性酶对抗疱疹病毒核苷磷酸化途径的分析。
Antimicrob Agents Chemother. 1996 Apr;40(4):920-3. doi: 10.1128/AAC.40.4.920.
4
Identification of varicella-zoster virus strains by PCR analysis of three repeat elements and a PstI-site-less region.通过对三个重复元件和一个无PstI位点区域进行PCR分析鉴定水痘带状疱疹病毒株
J Clin Microbiol. 1995 Mar;33(3):658-60. doi: 10.1128/jcm.33.3.658-660.1995.
5
In vitro activity of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine against newly isolated clinical varicella-zoster virus strains.（S）-9-（3-羟基-2-膦酰甲氧基丙基）腺嘌呤对新分离的临床水痘带状疱疹病毒株的体外活性
Eur J Clin Microbiol. 1987 Apr;6(2):158-60. doi: 10.1007/BF02018198.
6
Inhibition of varicella-zoster virus-induced DNA polymerase by a new guanosine analog, 9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine triphosphate.一种新型鸟苷类似物9-[4-羟基-2-(羟甲基)丁基]鸟嘌呤三磷酸对水痘带状疱疹病毒诱导的DNA聚合酶的抑制作用。
Antimicrob Agents Chemother. 1988 Aug;32(8):1137-42. doi: 10.1128/AAC.32.8.1137.
7
Efficacies of antiherpesvirus nucleosides against two strains of herpes simplex virus type 1 in Vero and human embryo lung fibroblast cells.抗疱疹病毒核苷类药物对两株1型单纯疱疹病毒在非洲绿猴肾细胞和人胚肺成纤维细胞中的疗效。
Antimicrob Agents Chemother. 1988 Jul;32(7):1046-52. doi: 10.1128/AAC.32.7.1046.
8
Effects of various nucleosides on antiviral activity and metabolism of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil against herpes simplex virus types 1 and 2.各种核苷对1-β-D-阿拉伯呋喃糖基-E-5-(2-溴乙烯基)尿嘧啶抗1型和2型单纯疱疹病毒的抗病毒活性及代谢的影响。
Antimicrob Agents Chemother. 1988 Oct;32(10):1547-51. doi: 10.1128/AAC.32.10.1547.
9
Antiviral activity of oxetanocins against varicella-zoster virus.氧杂环丁烷类化合物对水痘-带状疱疹病毒的抗病毒活性。
Antimicrob Agents Chemother. 1991 Jul;35(7):1512-4. doi: 10.1128/AAC.35.7.1512.
10
Random mutagenesis of the thymidine kinase gene of varicella-zoster virus.水痘带状疱疹病毒胸苷激酶基因的随机诱变
J Virol. 1992 Apr;66(4):2118-24. doi: 10.1128/JVI.66.4.2118-2124.1992.
本文引用的文献
1
MUTANT STRAINS OF HERPES SIMPLEX DEFICIENT IN THYMIDINE KINASE-INDUCING ACTIVITY.胸苷激酶诱导活性缺陷的单纯疱疹突变株。
Virology. 1964 Apr;22:493-502. doi: 10.1016/0042-6822(64)90070-4.
2
Bovid herpesvirus type-1 (infectious bovine rhinotracheitis virus)-induced thymidine kinase.牛疱疹病毒1型（传染性牛鼻气管炎病毒）诱导的胸苷激酶
Virology. 1982 Apr 15;118(1):191-201. doi: 10.1016/0042-6822(82)90332-4.
3
Alterations in substrate specificity and physicochemical properties of deoxythymidine kinase of a drug-resistant herpes simplex virus type 1 mutant.一株耐药单纯疱疹病毒1型突变体的脱氧胸苷激酶的底物特异性和物理化学性质的改变
J Virol. 1983 Jun;46(3):901-8. doi: 10.1128/JVI.46.3.901-908.1983.
4
Comparative efficacy of antiherpes drugs against various strains of varicella-zoster virus.抗疱疹药物对不同水痘-带状疱疹病毒株的疗效比较
J Infect Dis. 1983 Mar;147(3):576-84. doi: 10.1093/infdis/147.3.576.
5
Thymidine kinase deletion mutants of herpes simplex virus type 1.单纯疱疹病毒1型胸苷激酶缺失突变体
J Gen Virol. 1982 Dec;63(2):277-95. doi: 10.1099/0022-1317-63-2-277.
6
DNA sequence analysis of an immediate-early gene region of the herpes simplex virus type 1 genome (map coordinates 0.950 to 0.978).单纯疱疹病毒1型基因组即刻早期基因区域（图谱坐标0.950至0.978）的DNA序列分析
J Gen Virol. 1982 Sep;62 (Pt 1):1-15. doi: 10.1099/0022-1317-62-1-1.
7
Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-beta-D-arabinofuranosyladenine.单纯疱疹病毒DNA聚合酶基因的突变可赋予对9-β-D-阿拉伯呋喃糖基腺嘌呤的抗性。
J Virol. 1982 Mar;41(3):909-18. doi: 10.1128/JVI.41.3.909-918.1982.
8
In vitro susceptibility of varicella-zoster virus to E-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.水痘带状疱疹病毒对E-5-（2-溴乙烯基）-2'-脱氧尿苷及相关化合物的体外敏感性
Antimicrob Agents Chemother. 1982 Jan;21(1):33-8. doi: 10.1128/AAC.21.1.33.
9
Inhibitory effects of antiherpesviral thymidine analogs against varicella-zoster virus.抗疱疹病毒胸苷类似物对水痘带状疱疹病毒的抑制作用。
Antimicrob Agents Chemother. 1982 Feb;21(2):358-61. doi: 10.1128/AAC.21.2.358.
10
Evidence for control of herpes simplex virus mutagenesis by the viral DNA polymerase.病毒DNA聚合酶对单纯疱疹病毒诱变进行控制的证据。
Virology. 1982 Jan 30;116(2):535-43. doi: 10.1016/0042-6822(82)90146-5.
Zotero 插件