在使用青蒿琥酯-阿莫地喹进行常规治疗的头5年期间，卡萨芒斯地区（塞内加尔西南部）恶性疟原虫对抗疟药物的体外敏感性。
Plasmodium falciparum in vitro susceptibility to antimalarial drugs in Casamance (southwestern Senegal) during the first 5 years of routine use of artesunate-amodiaquine.
作者信息
Agnamey P, Brasseur P, de Pecoulas P Eldin, Vaillant Michel, Olliaro P
机构信息
Laboratoire de Parasitologie-Mycologie, Hôpital Hôtel Dieu--Broussais, Université Paris V, France.
出版信息
Antimicrob Agents Chemother. 2006 Apr;50(4):1531-4. doi: 10.1128/AAC.50.4.1531-1534.2006.
Abstract
We have monitored the in vitro sensitivities of Plasmodium falciparum isolates predeployment and during the deployment of artesunate plus amodiaquine treatment in Mlomp, Casamance (southwestern Senegal) during 2000 to 2004. Parasites remained susceptible to both drugs. Chloroquine resistance levels were high but stable. Quinine continues to be effective.
摘要
2000年至2004年期间，我们监测了在塞内加尔西南部卡萨芒斯地区姆隆普开展青蒿琥酯加阿莫地喹治疗前及治疗期间恶性疟原虫分离株的体外敏感性。疟原虫对这两种药物均保持敏感。氯喹耐药水平较高但稳定。奎宁仍然有效。
相似文献
1
Plasmodium falciparum in vitro susceptibility to antimalarial drugs in Casamance (southwestern Senegal) during the first 5 years of routine use of artesunate-amodiaquine.在使用青蒿琥酯-阿莫地喹进行常规治疗的头5年期间，卡萨芒斯地区（塞内加尔西南部）恶性疟原虫对抗疟药物的体外敏感性。
Antimicrob Agents Chemother. 2006 Apr;50(4):1531-4. doi: 10.1128/AAC.50.4.1531-1534.2006.
2
[Comparison of sensitivity of artesunate-sensitive and artesunate-resistant Plasmodium falciparum to chloroquine and amodiaquine].青蒿琥酯敏感和耐药恶性疟原虫对氯喹和氨酚喹敏感性的比较
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1999;17(6):353-5.
3
Artemisinin-based combination therapy for uncomplicated Plasmodium falciparum malaria in Colombia.基于青蒿素的联合疗法治疗哥伦比亚非复杂性恶性疟原虫疟疾。
Malar J. 2007 Feb 28;6:25. doi: 10.1186/1475-2875-6-25.
4
Confirmation of Plasmodium falciparum in vitro resistance to monodesethylamodiaquine and chloroquine in Dakar, Senegal, in 2015.2015年在塞内加尔达喀尔对恶性疟原虫对单去乙基阿莫地喹和氯喹的体外耐药性的确认
Malar J. 2017 Mar 16;16(1):118. doi: 10.1186/s12936-017-1773-4.
5
Artesunate-amodiaquine for the treatment of uncomplicated malaria.青蒿琥酯-阿莫地喹治疗非复杂性疟疾。
Expert Opin Investig Drugs. 2007 Jul;16(7):1079-85. doi: 10.1517/13543784.16.7.1079.
6
In vitro assessment of artesunate, artemether and amodiaquine susceptibility and molecular analysis of putative resistance-associated mutations of Plasmodium falciparum from São Tomé and Príncipe.圣多美和普林西比恶性疟原虫对青蒿琥酯、蒿甲醚和阿莫地喹敏感性的体外评估及假定抗性相关突变的分子分析。
Trop Med Int Health. 2007 Mar;12(3):353-62. doi: 10.1111/j.1365-3156.2006.01789.x.
7
In-vitro activity of pyronaridine and amodiaquine against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial agents.与标准抗疟药物相比，咯萘啶和氨酚喹对恶性疟原虫非洲分离株（塞内加尔）的体外活性。
J Antimicrob Chemother. 1998 Sep;42(3):333-9. doi: 10.1093/jac/42.3.333.
8
In vitro susceptibility of Gabonese wild isolates of Plasmodium falciparum to artemether, and comparison with chloroquine, quinine, halofantrine and amodiaquine.加蓬恶性疟原虫野生分离株对蒿甲醚的体外敏感性及其与氯喹、奎宁、卤泛群和阿莫地喹的比较。
Parasitology. 1998 Dec;117 ( Pt 6):541-5. doi: 10.1017/s0031182098003400.
9
In vitro monitoring of Plasmodium falciparum susceptibility to artesunate, mefloquine, quinine and chloroquine in Cambodia: 2001-2002.2001 - 2002年柬埔寨恶性疟原虫对青蒿琥酯、甲氟喹、奎宁和氯喹敏感性的体外监测
Acta Trop. 2005 Jan;93(1):31-40. doi: 10.1016/j.actatropica.2004.09.002.
10
Antibiotics for prophylaxis of Plasmodium falciparum infections: in vitro activity of doxycycline against Senegalese isolates.用于预防恶性疟原虫感染的抗生素：多西环素对塞内加尔分离株的体外活性
Am J Trop Med Hyg. 2000 Jan;62(1):82-5. doi: 10.4269/ajtmh.2000.62.82.
引用本文的文献
1
Bionomics of Anopheles gambiae complex (Diptera: Culicidae) and malaria transmission pattern in a pre-elimination area in South-Western Senegal.塞内加尔西南部一个疟疾消除前地区冈比亚按蚊复合体（双翅目：蚊科）的生物学特性及疟疾传播模式
Malar J. 2025 Jul 4;24(1):215. doi: 10.1186/s12936-025-05411-9.
2
HDSS Profile: Mlomp Health and Demographic Surveillance System (Mlomp HDSS), Senegal.卫生和人口监测系统简介：塞内加尔姆隆普卫生和人口监测系统（姆隆普HDSS）。
Int J Epidemiol. 2018 Aug 1;47(4):1025-1033. doi: 10.1093/ije/dyy075.
3
Plasmodium falciparum susceptibility to anti-malarial drugs in Dakar, Senegal, in 2010: an ex vivo and drug resistance molecular markers study.2010 年塞内加尔达喀尔地区恶性疟原虫对抗疟药物的敏感性：一项离体和耐药分子标志物研究。
Malar J. 2013 Mar 20;12:107. doi: 10.1186/1475-2875-12-107.
4
Prevalence of molecular markers of Plasmodium falciparum drug resistance in Dakar, Senegal.塞内加尔达喀尔地区恶性疟原虫耐药相关分子标志物的流行情况。
Malar J. 2012 Jun 13;11:197. doi: 10.1186/1475-2875-11-197.
5
Ex vivo susceptibility of Plasmodium falciparum isolates from Dakar, Senegal, to seven standard anti-malarial drugs.塞内加尔达喀尔地区分离的恶性疟原虫对 7 种标准抗疟药物的体外敏感性。
Malar J. 2011 Oct 20;10:310. doi: 10.1186/1475-2875-10-310.
6
Limited ability of Plasmodium falciparum pfcrt, pfmdr1, and pfnhe1 polymorphisms to predict quinine in vitro sensitivity or clinical effectiveness in Uganda.在乌干达，疟原虫 pfcrt、pfmdr1 和 pfnhe1 多态性对预测奎宁体外敏感性或临床疗效的能力有限。
Antimicrob Agents Chemother. 2011 Feb;55(2):615-22. doi: 10.1128/AAC.00954-10. Epub 2010 Nov 15.
7
In vitro activities of quinine and other antimalarials and pfnhe polymorphisms in Plasmodium isolates from Kenya.肯尼亚分离疟原虫株中奎宁和其他抗疟药物的体外活性与 pfnep 多态性。
Antimicrob Agents Chemother. 2010 Aug;54(8):3302-7. doi: 10.1128/AAC.00325-10. Epub 2010 Jun 1.
8
Understanding human-Plasmodium falciparum immune interactions uncovers the immunological role of worms.了解人类-恶性疟原虫免疫相互作用揭示了蠕虫的免疫学作用。
PLoS One. 2010 Feb 19;5(2):e9309. doi: 10.1371/journal.pone.0009309.
9
Selection of parasites with diminished drug susceptibility by amodiaquine-containing antimalarial regimens in Uganda.乌干达含阿莫地喹抗疟方案对药物敏感性降低的寄生虫的选择。
J Infect Dis. 2009 Dec 1;200(11):1650-7. doi: 10.1086/647988.
10
Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial.奎宁与蒿甲醚-本芴醇治疗乌干达儿童单纯性恶性疟的疗效比较：随机试验
BMJ. 2009 Jul 21;339:b2763. doi: 10.1136/bmj.b2763.
本文引用的文献
1
Economic evaluation of a policy change from single-agent treatment for suspected malaria to artesunate-amodiaquine for microscopically confirmed uncomplicated falciparum malaria in the Oussouye District of south-western Senegal.对塞内加尔西南部乌苏耶区一项政策变化的经济评估，该政策变化是从对疑似疟疾采用单药治疗转变为对显微镜确诊的非复杂性恶性疟采用青蒿琥酯-阿莫地喹治疗。
Trop Med Int Health. 2005 Sep;10(9):926-33. doi: 10.1111/j.1365-3156.2005.01482.x.
2
Combating malaria morbidity and mortality by reducing transmission.通过减少传播来对抗疟疾的发病率和死亡率。
Parasitol Today. 1996 Jun;12(6):236-40. doi: 10.1016/0169-4758(96)10015-6.
3
Amodiaquine-artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomised, multicentre trial.阿莫地喹-青蒿琥酯与阿莫地喹治疗非洲儿童非复杂性恶性疟原虫疟疾的疗效比较：一项随机、多中心试验。
Lancet. 2002 Apr 20;359(9315):1365-72. doi: 10.1016/s0140-6736(02)08348-4.
4
A colorimetric in vitro drug sensitivity assay for Plasmodium falciparum based on a highly sensitive double-site lactate dehydrogenase antigen-capture enzyme-linked immunosorbent assay.基于高灵敏度双位点乳酸脱氢酶抗原捕获酶联免疫吸附测定的恶性疟原虫比色体外药物敏感性测定。
Am J Trop Med Hyg. 2001 May-Jun;64(5-6):233-41. doi: 10.4269/ajtmh.2001.64.233.
5
Evaluation under field conditions of the colourimetric DELI-microtest for the assessment of Plasmodium falciparum drug resistance.用于评估恶性疟原虫耐药性的比色DELI微试验在现场条件下的评估
Trans R Soc Trop Med Hyg. 2001 Jan-Feb;95(1):100-3. doi: 10.1016/s0035-9203(01)90351-7.
6
Amodiaquine remains effective for treating uncomplicated malaria in west and central Africa.阿莫地喹对治疗西非和中非的非复杂性疟疾仍然有效。
Trans R Soc Trop Med Hyg. 1999 Nov-Dec;93(6):645-50. doi: 10.1016/s0035-9203(99)90083-4.
7
In-vitro activity of pyronaridine and amodiaquine against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial agents.与标准抗疟药物相比，咯萘啶和氨酚喹对恶性疟原虫非洲分离株（塞内加尔）的体外活性。
J Antimicrob Chemother. 1998 Sep;42(3):333-9. doi: 10.1093/jac/42.3.333.
8
Metabolism of beta-arteether to dihydroqinghaosu by human liver microsomes and recombinant cytochrome P450.人肝微粒体和重组细胞色素P450将β-蒿甲醚代谢为二氢青蒿素
Drug Metab Dispos. 1998 Apr;26(4):313-7.
9
10
Amodiaquine as a prodrug: importance of metabolite(s) in the antimalarial effect of amodiaquine in humans.阿莫地喹作为前体药物：代谢物在阿莫地喹对人类抗疟作用中的重要性。
Life Sci. 1985 Jan 7;36(1):53-62. doi: 10.1016/0024-3205(85)90285-1.
Zotero 插件