Woodland J, Vernon-Roberts B, Swettenham K V, Currey H L
Ann Rheum Dis. 1977 Apr;36(2):160-5. doi: 10.1136/ard.36.2.160.
The fluid and cellular phases of the inflammatory response were measured using a technique employing subcutaneous implantation of polyurethane foam cubes impregnated with heat-killed Mycobacterium tuberculosis. Fluribiprofen and prednisolone were equipotent and were capable of almost completely suppressing fluid and cellular responses, while alclofenac was less potent at nontoxic dose levels. Study of the patterns of cellular exudation by image analysing computer showed that alcofenac appears unique in that it produces a well-defined cell-free zone between the edge of the implanted cubes and a band of neutrophil polymorphs within the cubes.
采用皮下植入浸有热灭活结核分枝杆菌的聚氨酯泡沫立方体的技术，对炎症反应的液体和细胞阶段进行了测量。氟比洛芬和泼尼松龙具有同等效力，几乎能够完全抑制液体和细胞反应，而在无毒剂量水平下，阿氯芬酸的效力较低。通过图像分析计算机对细胞渗出模式的研究表明，阿氯芬酸显得独特，因为它在植入立方体的边缘与立方体内的中性粒细胞多形核细胞带之间产生了一个界限分明的无细胞区。
