Aylward M, Parker R J, Holly F, Maddock J, Davies D B
Br Med J. 1975 Apr 5;2(5961):7-9. doi: 10.1136/bmj.2.5961.7.
Indomethacin and alclofenac were compared for 13 months under double-blind conditions in 109 patients with active, classical, or definite rheumatoid arthritis at a relatively early stage of the disease. Both indomethacin and alclofenac were clearly effective: most patients either improved or remained as well controlled as on entry. Alclofenac proved the more effective drug, however, producing a significantly greater reduction in morning stiffness, articular index, and erythrocyte sedimentation rate, and only in the alclofenac-treated group did functional capacity improve and latex-agglutination titres diminish. Comprehensive laborabory tests showed no significant deviation from normal which could have been attributed to either drug.
在双盲条件下，对109例处于疾病相对早期的活动型、典型或确诊类风湿性关节炎患者，将吲哚美辛和阿氯芬酸进行了为期13个月的比较。吲哚美辛和阿氯芬酸均明显有效：大多数患者病情改善或维持与入组时相同的良好控制状态。然而，阿氯芬酸被证明是更有效的药物，它能使晨僵、关节指数和红细胞沉降率显著降低，而且只有在接受阿氯芬酸治疗的组中，功能能力得到改善，乳胶凝集滴度降低。全面的实验室检查显示，未出现可归因于任何一种药物的与正常情况的显著偏差。
