类风湿关节炎中的中性粒细胞趋化作用。青霉胺、金盐和左旋咪唑的影响。
Neutrophil chemotaxis in rheumatoid arthritis. Effect of D-penicillamine, gold salts, and levamisole.
作者信息
Mowat A G
出版信息
Ann Rheum Dis. 1978 Feb;37(1):1-8. doi: 10.1136/ard.37.1.1.
Abstract
The effect of therapeutic concentrations of D-penicillamine, sodium aurothiomalate, and levamisole on in vitro neutrophil chemotaxis and random migration in normal subjects and patients with rheumatoid arthritis was studied. D-penicillamine produced no changes. Sodium aurothiomalate produced dose-related reductions in chemotaxis in normal subjects and in patients who had a good clinical response to gold therapy, while patients who had failed to respond to gold showed a minimal nondose dependent reduction. Levamisole produced dose-dependent stimulation of chemotaxis, a greater effect found with the patients cells. Neutrophil chemotaxis improved to normal values in most patients responding to several months of D-penicillamine treatment but showed an immediate and marked stimulation in patients treated with levamisole.
摘要
研究了治疗浓度的D-青霉胺、硫代苹果酸金钠和左旋咪唑对正常人和类风湿性关节炎患者体外中性粒细胞趋化性及随机游走的影响。D-青霉胺未产生变化。硫代苹果酸金钠使正常人和对金疗法有良好临床反应的患者的趋化性呈剂量相关降低，而对金无反应的患者则有最小的非剂量依赖性降低。左旋咪唑产生剂量依赖性趋化性刺激，对患者细胞的作用更大。大多数对几个月D-青霉胺治疗有反应的患者中性粒细胞趋化性改善至正常水平，但在用左旋咪唑治疗的患者中显示出立即且显著的刺激。
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