Fouchet D, Marchandeau S, Langlais M, Pontier D
UMR-CNRS 5558, Biométrie et Biologie Evolutive, Université Claude Bernard Lyon 1, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne Cedex, France.
J Theor Biol. 2006 Sep 7;242(1):81-9. doi: 10.1016/j.jtbi.2006.02.003. Epub 2006 Mar 31.
Myxomatosis is a leporipoxvirus that infects the european rabbit, inducing a high mortality rate. Observations lead us to hypothesize that a rabbit carrying maternal antibodies (or having recovered) can be infected (or re-infected) upon being exposed (or re-exposed) to the virus. Infection will lead to mild disease, boosting host immune protection. Using a modelling approach we show that this phenomenon may lead to a difference of impact of myxomatosis according to its transmission rate. Young are exposed when they still carry maternal antibodies and develop a mild disease in high transmission populations. Our results show that the impact of myxomatosis is generally higher in epidemic situations compared to populations where the virus circulates all the year. As a consequence, waning of acquired immunity and the continuous supply of newborn along the year may reduce the impact of the disease.
黏液瘤病是一种感染欧洲兔的兔痘病毒，会导致高死亡率。观察结果使我们推测，携带母源抗体（或已康复）的兔子在接触（或再次接触）该病毒时可能会被感染（或再次感染）。感染会导致轻症疾病，增强宿主的免疫保护。通过建模方法，我们表明这种现象可能导致黏液瘤病根据其传播率产生不同的影响。幼兔在仍携带母源抗体时接触病毒，并在高传播率种群中患轻症疾病。我们的结果表明，与病毒常年传播的种群相比，黏液瘤病在流行情况下的影响通常更高。因此，获得性免疫力的减弱以及全年新生儿的持续供应可能会降低该疾病的影响。
