Siegsmund M, Wayss K, Amtmann E
Institute for Experimental Pathology, German Cancer Research Center, Heidelberg.
J Gen Virol. 1991 Nov;72 ( Pt 11):2787-9. doi: 10.1099/0022-1317-72-11-2787.
The skin of animals of a laboratory strain of Mastomys natalensis carrying endogenous, latent papillomavirus genomes was irritated by scratching with glasspaper. Hyperproliferation of the epidermis and amplification of viral DNA followed this treatment, and in approximately 27% of the animals virus-producing papillomas were induced.
携带内源性潜伏乳头瘤病毒基因组的南非多乳鼠实验室品系动物的皮肤,通过用砂纸刮擦使其受到刺激。这种处理后表皮出现过度增殖以及病毒DNA扩增,并且在大约27%的动物中诱发了产生病毒的乳头瘤。