Alaranta A, Alaranta H, Heliövaara M, Airaksinen M, Helenius I
Division of Social Pharmacy, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.
Int J Sports Med. 2006 Nov;27(11):919-25. doi: 10.1055/s-2006-923811. Epub 2006 Feb 14.
The present study aimed at determining the use of physician-prescribed medication in a large number of elite athletes compared with a representative control sample of the general population. Of all the athletes (N = 494) financially supported by the National Olympic Committee, 446 completed a structured questionnaire (response rate 90.3 %) in 2002. A control group (N = 1503, response rate 80.1 %) comprised an age-matched sample from the population-based study collected by the National Public Health Institute. Any prescribed medication was used by 34.5 % of the athletes and 24.9 % of the controls during the past seven days. The most frequently reported physician-prescribed medications among athletes during the previous seven days were anti-allergic medicines (12.6 % of the respondents), non-steroidal anti-inflammatory drugs (NSAIDs; 8.1 %), anti-asthmatic medicines (7.0 %), and oral antibiotics (2.7 %). The adjusted odds ratios (95 % CI) for the physician-prescribed medications used during the previous seven days was 2.42 (1.69 - 3.46), 3.63 (2.25 - 5.84), 3.42 (2.05 - 5.70), and 2.15 (1.03 - 4.45) for use of anti-allergic medication, NSAIDs, anti-asthmatic medication, and oral antibiotics, respectively, in the athletes compared with controls. Every fifth athlete reported some NSAID-related adverse effect. In conclusion, the athletes used NSAIDs, antibiotics, anti-asthmatic and anti-allergic medication significantly more often than a representative sample of age-matched controls. All these medicines have potential adverse effects that may have a deleterious impact on the maximum exercise performance of elite athletes. Adverse effects were commonly reported in connection with NSAID use.
本研究旨在确定与具有代表性的普通人群对照样本相比,大量精英运动员使用医生处方药物的情况。在所有由国家奥委会提供资金支持的运动员(N = 494)中,446名运动员于2002年完成了一份结构化问卷(回复率90.3%)。一个对照组(N = 1503,回复率80.1%)由国家公共卫生研究所开展的基于人群的研究中选取的年龄匹配样本组成。在过去七天内,34.5%的运动员和24.9%的对照组使用了任何处方药物。在之前七天内,运动员中最常报告的医生处方药物是抗过敏药物(12.6%的受访者)、非甾体抗炎药(NSAIDs;8.1%)、抗哮喘药物(7.0%)和口服抗生素(2.7%)。与对照组相比,运动员在之前七天内使用的医生处方药物的调整优势比(95%CI)分别为:使用抗过敏药物为2.42(1.69 - 3.46),使用NSAIDs为3.63(2.25 - 5.84),使用抗哮喘药物为3.42(2.05 - 5.7),使用口服抗生素为2.15(1.03 - 4.45)。每五分之一的运动员报告了一些与NSAIDs相关的不良反应。总之,运动员使用NSAIDs、抗生素、抗哮喘和抗过敏药物的频率明显高于年龄匹配的对照组代表性样本。所有这些药物都有潜在的不良反应,可能会对精英运动员的最大运动表现产生有害影响。与NSAIDs使用相关的不良反应很常见。