合成的d，l-共聚多肽溶液旋光性的统计研究。
A statistical study of optical rotation for synthetic d,l-copolypeptide solutions.
作者信息
Gotoh H, Lin S H, Eyring H
机构信息
Faculty of Textile Science and Technology, Shinshu University, Ueda, Nagaro, Japan.
出版信息
Proc Natl Acad Sci U S A. 1974 Dec;71(12):4675-8. doi: 10.1073/pnas.71.12.4675.
The right-handed helical fraction H(L) in a D,L-copolypeptide chain is evaluated by a simple probability theory for each L-fraction, p. The curves of optical rotation at a single wavelength against p for poly(gamma-benzyl-D,L-glutamate) and D,L-copolyleucine of a series of different D:L ratios in several positive helix-solvents are calculated with a modified semi-empirical Moffitt equation. From the comparison between the rotations calculated by us and observed by Downie et al., it is shown that to reproduce the observed rotations, the minimum number of right-handed helical nuclei or sequences of L-residues appropriate to the Moffitt equation are eight and four for degrees of polymerization 320 and 1860, respectively.
通过一种简单的概率理论，针对每个L-组分p，评估D,L-共聚多肽链中的右手螺旋分数H(L)。使用修正的半经验莫菲特方程，计算了在几种正螺旋溶剂中一系列不同D:L比的聚(γ-苄基-D,L-谷氨酸)和D,L-共聚亮氨酸在单一波长下的旋光曲线与p的关系。通过比较我们计算的旋光度和唐尼等人观察到的旋光度，结果表明，为了重现观察到的旋光度，对于聚合度为320和1860的情况，符合莫菲特方程的右手螺旋核或L-残基序列的最小数量分别为八个和四个。
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