Yancovitz S R, Des Jarlais D C, Peyser N P, Drew E, Friedmann P, Trigg H L, Robinson J W
Beth Israel Medical Center, New York, NY 10003.
Am J Public Health. 1991 Sep;81(9):1185-91. doi: 10.2105/ajph.81.9.1185.
Interim methadone maintenance has been proposed as a method of providing clinically effective services to heroin addicts waiting for treatment in standard comprehensive methadone maintenance programs.
A clinic that provided initial medical evaluation, methadone medication, and AIDS education, but did not include formal drug abuse counseling or other social support services was established in New York City. A sample of 301 volunteer subjects recruited from the waiting list for treatment in the Beth Israel methadone program were randomly assigned to immediate entry into the interim clinic or a control group.
There were no differences in initial levels of illicit drug use across the experimental and control groups. One-month urinalysis follow-up data showed a significant reduction in heroin use in the experimental group (from 63% positive at intake to 29% positive) with no change in the control group (62% to 60% positive). No significant change was observed in cocaine urinalyses (approximately 70% positive for both groups at intake and follow-up). A higher percentage of the experimental group were in treatment at 16-month follow-up (72% vs 56%).
Limited services interim methadone maintenance can reduce heroin use among persons awaiting entry into comprehensive treatment and increase the percentage entering treatment.
临时美沙酮维持治疗已被提议作为一种向等待标准综合美沙酮维持治疗项目的海洛因成瘾者提供临床有效服务的方法。
在纽约市设立了一家诊所，该诊所提供初步医学评估、美沙酮药物治疗和艾滋病教育，但不包括正规的药物滥用咨询或其他社会支持服务。从贝斯以色列美沙酮项目治疗等候名单中招募的301名志愿者受试者样本被随机分配到立即进入临时诊所组或对照组。
实验组和对照组在初始非法药物使用水平上没有差异。为期一个月的尿液分析随访数据显示，实验组海洛因使用量显著减少（从入组时的63%呈阳性降至29%呈阳性），而对照组没有变化（62%至60%呈阳性）。可卡因尿液分析未观察到显著变化（入组和随访时两组均约70%呈阳性）。在16个月的随访中，实验组接受治疗的比例更高（72%对56%）。
有限服务的临时美沙酮维持治疗可以减少等待进入综合治疗的人群中的海洛因使用，并提高进入治疗的比例。
