关于结合能的归因和可加性。
On the attribution and additivity of binding energies.
机构信息
Graduate Department of Biochemistry, Brandeis University, Waltham, Massachusetts 02254.
出版信息
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4046-50. doi: 10.1073/pnas.78.7.4046.
Abstract
It can be useful to describe the Gibbs free energy changes for the binding to a protein of a molecule, A-B, and of its component parts, A and B, in terms of the "intrinsic binding energies" of A and B, DeltaG(A) (i) and DeltaG(B) (i), and a "connection Gibbs energy," DeltaG(s) that is derived largely from changes in translational and rotational entropy. This empirical approach avoids the difficult or insoluble problem of interpreting observed DeltaH and TDeltaS values for aqueous solutions. The DeltaG(i) and DeltaG(s) terms can be large for binding to enzymes and other proteins.
摘要
将分子 A-B 与其组成部分 A 和 B 结合到蛋白质上的吉布斯自由能变化，可以用“A 和 B 的内在结合能”DeltaG(A)(i) 和 DeltaG(B)(i) 以及一个“连接吉布斯能”DeltaG(s) 来描述，这个连接吉布斯能主要来自于平移和旋转熵的变化。这种经验方法避免了对水溶液中观察到的 DeltaH 和 TDeltaS 值进行解释的困难或无法解决的问题。对于与酶和其他蛋白质的结合，DeltaG(i) 和 DeltaG(s) 项可能很大。
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