de Vet H C, Knipschild P G, Grol M E, Schouten H J, Sturmans F
Department of Epidemiology/Health Care Research, University of Limburg, Maastricht, The Netherlands.
Int J Epidemiol. 1991 Sep;20(3):603-10. doi: 10.1093/ije/20.3.603.
The effects of beta-carotene and several other dietary factors on the risk of cervical dysplasia were evaluated in a case-control study. Cases (n = 257) were the participants of a randomized trial assessing the effect of beta-carotene on cervical dysplasia. Controls (n = 705) were sampled from the general population. A postal questionnaire was used to obtain information about the frequency of consumption of several food items containing beta-carotene, retinol, vitamin C and dietary fibre. Information was also collected about other risk factors for cervical dysplasia, in order to adjust for possible confounding. To our surprise, we observed an increased risk of cervical dysplasia for women with a high intake of beta-carotene (odds ratio (OR) = 2.31; 95% confidence interval (CI): 1.27-4.19). No relationship was found with the intake of retinol, while both vitamin C and dietary fibre showed a weak and not statistically significant inverse relationship with cervical dysplasia. These findings do not support the hypothesis that beta-carotene protects against cervical dysplasia.
在一项病例对照研究中，评估了β-胡萝卜素和其他几种饮食因素对宫颈发育异常风险的影响。病例组（n = 257）为一项评估β-胡萝卜素对宫颈发育异常影响的随机试验的参与者。对照组（n = 705）从普通人群中抽样。通过邮寄问卷获取有关几种含β-胡萝卜素、视黄醇、维生素C和膳食纤维的食物摄入频率的信息。还收集了有关宫颈发育异常其他风险因素的信息，以便对可能的混杂因素进行调整。令我们惊讶的是，我们观察到β-胡萝卜素摄入量高的女性患宫颈发育异常的风险增加（比值比（OR）= 2.31；95%置信区间（CI）：1.27 - 4.19）。未发现与视黄醇摄入量有关，而维生素C和膳食纤维与宫颈发育异常均呈微弱且无统计学意义的负相关。这些发现不支持β-胡萝卜素可预防宫颈发育异常这一假说。
