Bassetti Claudio L, Hersberger Martin, Baumann Christian R
Department of Neurology, Universitätsspital Zürich, Frauenklinikstrasse 26, 8091 Zürich, Switzerland.
J Neurol. 2006 Aug;253(8):1030-3. doi: 10.1007/s00415-006-0153-8. Epub 2006 Apr 5.
Lipocalin-type prostaglandin D synthase (L-PGDS) is a brain enzyme, which produces prostaglandin D(2), a substance with endogenous somnogenic effects. Using a standardized protocol for immunonephelometric determination of cerebrospinal fluid (CSF) L-PGDS levels, we show that CSF L-PGDS levels are significantly lower in 34 patients with excessive daytime sleepiness when compared with levels in 22 healthy controls. Thus, L-PGDS may represent the first neurochemical measure of excessive daytime sleepiness.
脂联素型前列腺素D合成酶（L-PGDS）是一种脑酶，可产生前列腺素D2，一种具有内源性促眠作用的物质。通过采用标准化方案免疫比浊法测定脑脊液（CSF）中L-PGDS水平，我们发现，与22名健康对照者相比，34名日间过度嗜睡患者的脑脊液L-PGDS水平显著降低。因此，L-PGDS可能是日间过度嗜睡的首个神经化学指标。
