Barceló A, de la Peña M, Barbé F, Pierola J, Bosch M, Agustí A G N
Servei de Analisis Cliniques and Pneumologia, C/Andrea Doria 55, 07014 Palma de Mallorca, Spain.
Sleep Med. 2007 Aug;8(5):509-11. doi: 10.1016/j.sleep.2006.10.005. Epub 2007 May 18.
Excessive daytime sleepiness (EDS) occurs often in patients with obstructive sleep apnea syndrome (OSAS). However, not all patients present EDS. We hypothesized that the prostaglandin D2 system (PGD2) may be involved in the pathogenesis of EDS associated with OSAS.
We measured the levels of lipocalin-type PGD synthase (L-PGDS), the enzyme that produces PGD2, in the serum of 47 patients with OSAS (26 with and 21 without EDS) and 18 healthy controls.
Patients with EDS had higher levels of L-PGDS (0.73+/-0.06 mg/L) than patients without EDS (0.58+/-0.03 mg/L, p<0.05) and controls (0.62+/-0.02 mg/L, p<0.05). L-PGDS levels in patients without EDS and controls were similar.
The increased levels of circulating L-PGDS detected in OSAS patients with EDS suggest a possible role of the prostaglandin D system in the pathophysiology of daytime sleepiness in these patients.
阻塞性睡眠呼吸暂停综合征（OSAS）患者常出现日间过度嗜睡（EDS）。然而，并非所有患者都有EDS。我们推测前列腺素D2系统（PGD2）可能参与了与OSAS相关的EDS的发病机制。
我们检测了47例OSAS患者（26例有EDS，21例无EDS）和18名健康对照者血清中产生PGD2的酶——脂质运载蛋白型PGD合成酶（L-PGDS）的水平。
有EDS的患者L-PGDS水平（0.73±0.06 mg/L）高于无EDS的患者（0.58±0.03 mg/L，p<0.05）和对照者（0.62±0.02 mg/L，p<0.05）。无EDS的患者和对照者的L-PGDS水平相似。
在有EDS的OSAS患者中检测到循环L-PGDS水平升高，提示前列腺素D系统在这些患者日间嗜睡的病理生理学中可能起作用。
