Asawasinsopon R, Prapamontol T, Prakobvitayakit O, Vaneesorn Y, Mangklabruks A, Hock B
Environmental Science Ph.D. Program, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.
Environ Int. 2006 May;32(4):554-9. doi: 10.1016/j.envint.2006.01.001. Epub 2006 Feb 21.
It is now known that many organochlorines (OCs) act as endocrine disruptors, causing harmful effects on wildlife and humans. Several field and laboratory animal studies have reported that OCs cause adverse effects on thyroid hormone status. However, data regarding their effects on thyroid hormone status in humans are inconclusive. Because a developing fetus is especially sensitive to hormonal disruption by exposure to OCs, the adverse health effects on infants are of concern. The present study aimed to investigate the association between OC levels in maternal and cord serum, and the association between OC and thyroid hormone levels in cord serum. The study was performed with 39 mother-infant pairs from Mae Rim District of Chiang Mai Province, northern Thailand, who had normal delivery and full term gestation. Maternal blood was collected for measuring OCs and total lipids. Umbilical cord blood was collected for measuring OCs, total lipids, and thyroid hormones, including total thyroxine (TT(4)), free thyroxine (FT(4)), and thyroid stimulating hormone (TSH). 1,1-dichloro-2,2-di(4-chlorophenyl)ethylene (p,p'-DDE) had the highest level in all serum samples with a geometric mean of 1,191 ng/g lipids in maternal serum and 742 ng/g lipids in cord serum. The second highest level was that for 1,1,1-trichloro-2,2-di(4-chlorophenyl)ethane (p,p'-DDT), followed by 1,1-dichloro-2,2-di(4-chlorophenyl)ethane (p,p'-DDD). Levels of p,p'-DDE, p,p'-DDT, p,p'-DDD, and dieldrin in maternal serum were positively associated with levels in cord serum (r = 0.86, 0.77, 0.66, and 0.60, respectively; P<0.001). The important findings were that cord serum TT(4) levels were negatively associated with cord serum levels of p,p'-DDE (r = -0.37, P = 0.024), p,p'-DDT.3 (r = -0.33, P = 0.048), and 1,1-dichloro-2-(2-chlorophenyl)-2-(4-chlorophenyl)ethylene (o,p'-DDE) (r = -0.76, P = 0.019). These results therefore suggest that exposure to DDT and its metabolites during fetal development may cause some effects on thyroid hormonal status in infants.
现已知道，许多有机氯化合物（OCs）可作为内分泌干扰物，对野生动物和人类产生有害影响。多项野外和实验动物研究报告称，OCs会对甲状腺激素状态产生不利影响。然而，关于其对人类甲状腺激素状态影响的数据尚无定论。由于发育中的胎儿对接触OCs引起的激素干扰特别敏感，因此对婴儿的不良健康影响令人担忧。本研究旨在调查母体血清和脐带血清中OC水平之间的关联，以及脐带血清中OC与甲状腺激素水平之间的关联。该研究对泰国北部清迈府湄林县的39对母婴进行，这些母婴均正常分娩且足月妊娠。采集母体血液以测量OCs和总脂质。采集脐带血以测量OCs、总脂质和甲状腺激素，包括总甲状腺素（TT(4)）、游离甲状腺素（FT(4)）和促甲状腺激素（TSH）。在所有血清样本中，1,1-二氯-2,2-二（4-氯苯基）乙烯（p,p'-DDE）的水平最高，母体血清中的几何平均值为1,191 ng/g脂质，脐带血清中的几何平均值为742 ng/g脂质。第二高的水平是1,1,1-三氯-2,2-二（4-氯苯基）乙烷（p,p'-DDT），其次是1,1-二氯-2,2-二（4-氯苯基）乙烷（p,p'-DDD）。母体血清中p,p'-DDE、p,p'-DDT、p,p'-DDD和狄氏剂的水平与脐带血清中的水平呈正相关（r分别为0.86、0.77、0.66和0.60；P<0.001）。重要发现是，脐带血清TT(4)水平与脐带血清中p,p'-DDE（r = -0.37，P = 0.024）、p,p'-DDT.3（r = -0.33，P = 0.048）和1,1-二氯-2-（2-氯苯基）-2-（4-氯苯基）乙烯（o,p'-DDE）（r = -0.76，P = 0.019）的水平呈负相关。因此，这些结果表明，胎儿发育期间接触滴滴涕及其代谢物可能会对婴儿的甲状腺激素状态产生一些影响。
