Silvius John
Department of Biochemistry, McGill University, Montréal, Québec, Canada.
Q Rev Biophys. 2005 Nov;38(4):373-83. doi: 10.1017/S003358350600415X. Epub 2006 Apr 6.
The concept of 'lipid rafts' and related liquid-ordered membrane microdomains has attracted great attention in the field of membrane biology, both as a novel paradigm in models of membrane organization and for the potential importance of such domains in phenomena such as membrane signaling and the differential trafficking of various membrane components. Studies of biological and of model membranes have gone hand in hand in shaping our current picture of the possible organization and functions of liquid-ordered lipid microdomains in membranes. This essay discusses some important current questions concerning the existence and functional importance of lipid microdomains in mammalian cell membranes, and the potential as well as the limitations of using model systems to help to address such questions.
“脂筏”及相关的有序液相膜微区概念在膜生物学领域引起了极大关注，这既是膜组织模型中的一种新范式，也是因为这些微区在膜信号传导及各种膜成分的差异运输等现象中具有潜在重要性。对生物膜和模型膜的研究在形成我们目前关于膜中有序液相脂质微区可能的组织形式和功能的认识方面齐头并进。本文讨论了一些当前关于哺乳动物细胞膜中脂质微区的存在及其功能重要性的重要问题，以及使用模型系统来帮助解决此类问题的潜力和局限性。
