Lee Alison H, Ingraham Susan E, Kopp Monica, Foraida Mohamed I, Jazieh Abdul-Rahman
University Medical Center at Princeton, Princeton, NJ, USA.
Am J Clin Oncol. 2006 Apr;29(2):178-82. doi: 10.1097/01.coc.0000209369.44100.25.
The concurrent use of dietary supplements and prescription medications is common among patients with cancer. This study examines potential interactions between dietary supplements and prescription medications in a Veteran Hospital cancer population.
Eligible patients seen at the Hematology/Oncology clinic at the Veterans Administration Medical Center in Cincinnati, OH, were administered a survey to determine their use of dietary supplements. Medication profiles were compiled from patients' medical charts and pharmacy records. It was also noted whether supplementation was previously documented. Potential interactions between dietary supplements and prescription medications were identified from a literature search of documented interactions. Several demographic factors, including age, race, marital status, education and income, were assessed for differences between patients found to be at risk for interactions and those for whom no risks were identified.
Dietary supplements were used by 61% of patients. Multivitamins were the most common supplement (80.3%) followed by minerals (40.6%) and herbal preparations (24.8%). Of the 121 patients taking supplements, 65 patients (54%) reported taking more than one. A potential risk for interaction between dietary supplement and prescription medication was identified in 12% of patients taking supplementations. Three patients were at risk for multiple interactions. Veterans who were not currently married were more likely to be at risk for interactions (P = 0.024). Only 28% of patients taking dietary supplements had this supplementation documented in their medical record.
Dietary supplementation by a veteran cancer population is common. Interactions between the supplement and prescription medication is a potential problem. Patient-physician discussion and documentation of these issues should be systematically addressed.
癌症患者同时使用膳食补充剂和处方药的情况很常见。本研究调查了退伍军人医院癌症患者群体中膳食补充剂与处方药之间的潜在相互作用。
对俄亥俄州辛辛那提市退伍军人管理局医疗中心血液科/肿瘤科门诊的 eligible 患者进行调查，以确定他们对膳食补充剂的使用情况。从患者的病历和药房记录中整理出用药情况。还记录了之前是否有补充剂使用的记录。通过对已记录相互作用的文献检索，确定膳食补充剂与处方药之间的潜在相互作用。评估了几个人口统计学因素，包括年龄、种族、婚姻状况、教育程度和收入，以比较发现有相互作用风险的患者与未发现风险的患者之间的差异。
61% 的患者使用膳食补充剂。复合维生素是最常见的补充剂（80.3%），其次是矿物质（40.6%）和草药制剂（24.8%）。在121名服用补充剂的患者中，65名患者（54%）报告服用了不止一种。在服用补充剂的患者中，12% 被确定存在膳食补充剂与处方药相互作用的潜在风险。三名患者存在多种相互作用的风险。目前未婚的退伍军人更有可能存在相互作用的风险（P = 0.024）。服用膳食补充剂的患者中，只有28% 在其病历中有补充剂使用的记录。
退伍军人癌症患者群体中膳食补充很常见。补充剂与处方药之间的相互作用是一个潜在问题。患者与医生之间应系统地讨论并记录这些问题。
