Department of Public Health, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Department of Immunology and Molecular Biology, School of Biomedical and Laboratory Sciences, University of Gondar, P.o.Box: 196, Gondar, Ethiopia.
Syst Rev. 2021 Aug 12;10(1):223. doi: 10.1186/s13643-021-01786-3.
BACKGROUND: Syphilis remained a major cause of reproductive morbidity and poor pregnancy outcomes in developing countries. Previously, studies showed inconsistent results and failed to show the actual picture of the diseases in Ethiopia. Thus, the aim of this meta-analysis was, first, to determine the updated pooled prevalence of syphilis among pregnant women in Ethiopia and, second, to assess its associated factors. METHODS: A comprehensive search was made on PubMed, Google scholar, Science Direct, and African Journals Online databases to identify relevant articles. A random effects model was used to estimate pooled syphilis prevalence and odds ratio (OR) with the respective 95% confidence intervals (CIs) using STATA 14 statistical software. I statistics and Egger's regression test in conjunction with funnel plot was used to determine heterogeneity and publication bias among included studies respectively. RESULT: We identified 13 suitable studies in this analysis. Accordingly, the pooled prevalence of syphilis among pregnant women in Ethiopia was 2.32% (95% CI, 1.68-2.97). Specifically, syphilis prevalence was 2.53% (95% CI, 1.92-3.14%) and 1.90% (95% CI, 0.40-3.40%) as per the treponemal and non-ytreponemal diagnostic test, respectively. On the other hand, regional analysis indicated that 4.06% (95% CI, 2.86-5.26) in Southern Nations Nationalities and Peoples (SNNP), 2.16% (95% CI, 1.57-2.75) in Amhara and 1.46% (95% CI, 0.69-2.23) in Oromia region. Being married (OR, 0.37 (95% CI, 0.12-0.91%)) was less likely to develop syphilis. On the other hand, women with history of multiple sexual partner (OR, 2.98 (95% CI, 1.15-7.70)) and women with history of previous sexually transmitted infection (STI) (OR, 4.88 (95% CI, 1.35-17.62)) have higher risk to develop syphilis. Besides, the pooled syphilis-HIV coinfection was 0.80% (95% CI, 0.60-1.01%). CONCLUSION: This study provides evidence of relatively high prevalence of syphilis among pregnant women in Ethiopia. Therefore, it is recommended to further ramping up of current intervention measures to prevent future generations. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42020211650.
背景：梅毒仍然是发展中国家生殖发病率和不良妊娠结局的主要原因。此前的研究结果不一致，未能真实反映埃塞俄比亚的梅毒现状。因此，本荟萃分析的目的首先是确定埃塞俄比亚孕妇梅毒的最新汇总患病率，其次是评估其相关因素。
方法：我们在 PubMed、Google Scholar、Science Direct 和 African Journals Online 数据库上进行了全面检索，以确定相关文章。使用 STATA 14 统计软件，采用随机效应模型估计汇总梅毒患病率和比值比（OR）及其相应的 95%置信区间（CI）。使用 I 统计量和 Egger 回归检验以及漏斗图分别评估纳入研究的异质性和发表偏倚。
结果：我们在这项分析中确定了 13 项合适的研究。因此，埃塞俄比亚孕妇梅毒的汇总患病率为 2.32%（95%CI，1.68-2.97）。具体而言，根据密螺旋体和非密螺旋体诊断检测，梅毒患病率分别为 2.53%（95%CI，1.92-3.14%）和 1.90%（95%CI，0.40-3.40%）。另一方面，区域分析表明，在南部各族人民国家（SNNP）地区为 4.06%（95%CI，2.86-5.26），在阿姆哈拉地区为 2.16%（95%CI，1.57-2.75），在奥罗米亚地区为 1.46%（95%CI，0.69-2.23）。已婚（OR，0.37（95%CI，0.12-0.91%））发生梅毒的可能性较小。另一方面，有多个性伴侣史（OR，2.98（95%CI，1.15-7.70））和有既往性传播感染史（STI）（OR，4.88（95%CI，1.35-17.62））的妇女发生梅毒的风险更高。此外，梅毒-艾滋病毒合并感染的汇总患病率为 0.80%（95%CI，0.60-1.01%）。
结论：本研究提供了埃塞俄比亚孕妇梅毒患病率较高的证据。因此，建议进一步加强当前的干预措施，以防止下一代感染梅毒。
系统评价注册：PROSPERO CRD42020211650。
Infect Dis Obstet Gynecol. 2020
BMC Pregnancy Childbirth. 2018-1-18
Int J Womens Health. 2022-4-1
Curr Epidemiol Rep. 2018-3
Rev Saude Publica. 2017-8-17
Zotero 插件
